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439 Publications
2019 | Journal Article | IST-REx-ID: 7182 |

Systematic Y2H screening reveals extensive effector-complex formation
A. Alcântara, J. Bosch, F. Nazari, G. Hoffmann, M.C. Gallei, S. Uhse, M.A. Darino, T. Olukayode, D. Reumann, L. Baggaley, A. Djamei, Frontiers in Plant Science 10 (2019).
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A. Alcântara, J. Bosch, F. Nazari, G. Hoffmann, M.C. Gallei, S. Uhse, M.A. Darino, T. Olukayode, D. Reumann, L. Baggaley, A. Djamei, Frontiers in Plant Science 10 (2019).
2019 | Conference Paper | IST-REx-ID: 7183 |

Deciding fast termination for probabilistic VASS with nondeterminism
T. Brázdil, K. Chatterjee, A. Kucera, P. Novotný, D. Velan, in:, International Symposium on Automated Technology for Verification and Analysis, Springer Nature, 2019, pp. 462–478.
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T. Brázdil, K. Chatterjee, A. Kucera, P. Novotný, D. Velan, in:, International Symposium on Automated Technology for Verification and Analysis, Springer Nature, 2019, pp. 462–478.
2019 | Thesis | IST-REx-ID: 7186 |

Mechanosensation of tight junctions depends on ZO-1 phase separation and flow
C. Schwayer, Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow, IST Austria, 2019.
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C. Schwayer, Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow, IST Austria, 2019.
2019 | Journal Article | IST-REx-ID: 7190 |

In-medium bound states of two bosonic impurities in a one-dimensional Fermi gas
D. Huber, H.-W. Hammer, A. Volosniev, Physical Review Research 1 (2019).
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| arXiv
D. Huber, H.-W. Hammer, A. Volosniev, Physical Review Research 1 (2019).
2019 | Journal Article | IST-REx-ID: 7197 |

Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA
P.R. Dos Santos Caldas, M.D. Lopez Pelegrin, D.J.G. Pearce, N.B. Budanur, J. Brugués, M. Loose, Nature Communications 10 (2019).
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P.R. Dos Santos Caldas, M.D. Lopez Pelegrin, D.J.G. Pearce, N.B. Budanur, J. Brugués, M. Loose, Nature Communications 10 (2019).
2019 | Journal Article | IST-REx-ID: 72 |

Limit law of a second class particle in TASEP with non-random initial condition
P. Ferrari, P. Ghosal, P. Nejjar, Annales de l’institut Henri Poincare (B) Probability and Statistics 55 (2019) 1203–1225.
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P. Ferrari, P. Ghosal, P. Nejjar, Annales de l’institut Henri Poincare (B) Probability and Statistics 55 (2019) 1203–1225.
2019 | Journal Article | IST-REx-ID: 7200 |

Effect of anomalous diffusion of fluctuating Cooper pairs on the density of states of superconducting NbN thin films
P. Brighi, M. Grilli, B. Leridon, S. Caprara, Physical Review B 100 (2019).
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P. Brighi, M. Grilli, B. Leridon, S. Caprara, Physical Review B 100 (2019).
2019 | Conference Paper | IST-REx-ID: 7201 |

SparCML: High-performance sparse communication for machine learning
C. Renggli, S. Ashkboos, M. Aghagolzadeh, D.-A. Alistarh, T. Hoefler, in:, International Conference for High Performance Computing, Networking, Storage and Analysis, SC, ACM, 2019.
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C. Renggli, S. Ashkboos, M. Aghagolzadeh, D.-A. Alistarh, T. Hoefler, in:, International Conference for High Performance Computing, Networking, Storage and Analysis, SC, ACM, 2019.
2019 | Journal Article | IST-REx-ID: 7202 |

A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture
A. Llorca, G. Ciceri, R.J. Beattie, F.K. Wong, G. Diana, E. Serafeimidou-Pouliou, M. Fernández-Otero, C. Streicher, S.J. Arnold, M. Meyer, S. Hippenmeyer, M. Maravall, O. Marín, ELife 8 (2019).
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A. Llorca, G. Ciceri, R.J. Beattie, F.K. Wong, G. Diana, E. Serafeimidou-Pouliou, M. Fernández-Otero, C. Streicher, S.J. Arnold, M. Meyer, S. Hippenmeyer, M. Maravall, O. Marín, ELife 8 (2019).
2019 | Journal Article | IST-REx-ID: 7210 |

Population structure determines the tradeoff between fixation probability and fixation time
J. Tkadlec, A. Pavlogiannis, K. Chatterjee, M.A. Nowak, Communications Biology 2 (2019).
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J. Tkadlec, A. Pavlogiannis, K. Chatterjee, M.A. Nowak, Communications Biology 2 (2019).
2019 | Conference Paper | IST-REx-ID: 7213 |

A persistent homology perspective to the link prediction problem
S. Bhatia, B. Chatterjee, D. Nathani, M. Kaul, in:, Complex Networks and Their Applications VIII, Springer Nature, 2019, pp. 27–39.
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S. Bhatia, B. Chatterjee, D. Nathani, M. Kaul, in:, Complex Networks and Their Applications VIII, Springer Nature, 2019, pp. 27–39.
2019 | Journal Article | IST-REx-ID: 7214 |

Recovering rearranged cancer chromosomes from karyotype graphs
S. Aganezov, I. Zban, V. Aksenov, N. Alexeev, M.C. Schatz, BMC Bioinformatics 20 (2019).
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S. Aganezov, I. Zban, V. Aksenov, N. Alexeev, M.C. Schatz, BMC Bioinformatics 20 (2019).
2019 | Conference Paper | IST-REx-ID: 7216
LiveTraVeL: Real-time matching of transit vehicle trajectories to transit routes at scale
G.F. Osang, J. Cook, A. Fabrikant, M. Gruteser, in:, 2019 IEEE Intelligent Transportation Systems Conference, IEEE, 2019.
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G.F. Osang, J. Cook, A. Fabrikant, M. Gruteser, in:, 2019 IEEE Intelligent Transportation Systems Conference, IEEE, 2019.
2019 | Journal Article | IST-REx-ID: 7225 |

Frontiers in microfluidics, a teaching resource review
J. Merrin, Bioengineering 6 (2019).
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J. Merrin, Bioengineering 6 (2019).
2019 | Journal Article | IST-REx-ID: 7226 |

Introduction to the Special Collection: International Congress on Mathematical Physics (ICMP) 2018
V. Jaksic, R. Seiringer, Journal of Mathematical Physics 60 (2019).
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V. Jaksic, R. Seiringer, Journal of Mathematical Physics 60 (2019).
2019 | Conference Paper | IST-REx-ID: 7228
Scalable FIFO channels for programming via communicating sequential processes
N. Koval, D.-A. Alistarh, R. Elizarov, in:, Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer Nature, 2019, pp. 317–333.
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N. Koval, D.-A. Alistarh, R. Elizarov, in:, Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer Nature, 2019, pp. 317–333.
2019 | Conference Paper | IST-REx-ID: 7230 |

Extending simple drawings
A.M. Arroyo Guevara, M. Derka, I. Parada, in:, Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer Nature, 2019, pp. 230–243.
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A.M. Arroyo Guevara, M. Derka, I. Parada, in:, Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer Nature, 2019, pp. 230–243.
2019 | Conference Paper | IST-REx-ID: 7231 |

Piecewise robust barrier tubes for nonlinear hybrid systems with uncertainty
H. Kong, E. Bartocci, Y. Jiang, T.A. Henzinger, in:, Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer Nature, 2019, pp. 123–141.
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H. Kong, E. Bartocci, Y. Jiang, T.A. Henzinger, in:, Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer Nature, 2019, pp. 123–141.
2019 | Conference Paper | IST-REx-ID: 7232
Mixed-time signal temporal logic
T. Ferrere, O. Maler, D. Nickovic, in:, Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer Nature, 2019, pp. 59–75.
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T. Ferrere, O. Maler, D. Nickovic, in:, Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer Nature, 2019, pp. 59–75.
2019 | Conference Paper | IST-REx-ID: 7233
Resonant electro-optic frequency comb generation in lithium niobate disk resonator inside a microwave cavity
A.R. Rueda Sanchez, F. Sedlmeir, G. Leuchs, M. Kumari, H.G.L. Schwefel, in:, Nonlinear Optics, OSA Technical Digest, OSA, 2019.
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A.R. Rueda Sanchez, F. Sedlmeir, G. Leuchs, M. Kumari, H.G.L. Schwefel, in:, Nonlinear Optics, OSA Technical Digest, OSA, 2019.
2019 | Journal Article | IST-REx-ID: 7275 |

Singlet oxygen from cation driven superoxide disproportionation and consequences for aprotic metal–O2 batteries
E. Mourad, Y.K. Petit, R. Spezia, A. Samojlov, F.F. Summa, C. Prehal, C. Leypold, N. Mahne, C. Slugovc, O. Fontaine, S. Brutti, S.A. Freunberger, Energy & Environmental Science 12 (2019) 2559–2568.
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E. Mourad, Y.K. Petit, R. Spezia, A. Samojlov, F.F. Summa, C. Prehal, C. Leypold, N. Mahne, C. Slugovc, O. Fontaine, S. Brutti, S.A. Freunberger, Energy & Environmental Science 12 (2019) 2559–2568.
2019 | Journal Article | IST-REx-ID: 7276 |

DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for metal-O2 cells
Y.K. Petit, C. Leypold, N. Mahne, E. Mourad, L. Schafzahl, C. Slugovc, S.M. Borisov, S.A. Freunberger, Angewandte Chemie International Edition 58 (2019) 6535–6539.
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Y.K. Petit, C. Leypold, N. Mahne, E. Mourad, L. Schafzahl, C. Slugovc, S.M. Borisov, S.A. Freunberger, Angewandte Chemie International Edition 58 (2019) 6535–6539.
2019 | Journal Article | IST-REx-ID: 7280 |

Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen
W.-J. Kwak, H. Kim, Y.K. Petit, C. Leypold, T.T. Nguyen, N. Mahne, P. Redfern, L.A. Curtiss, H.-G. Jung, S.M. Borisov, S.A. Freunberger, Y.-K. Sun, Nature Communications 10 (2019).
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W.-J. Kwak, H. Kim, Y.K. Petit, C. Leypold, T.T. Nguyen, N. Mahne, P. Redfern, L.A. Curtiss, H.-G. Jung, S.M. Borisov, S.A. Freunberger, Y.-K. Sun, Nature Communications 10 (2019).
2019 | Journal Article | IST-REx-ID: 7281 |

Mutual conservation of redox mediator and singlet oxygen quencher in Lithium–Oxygen batteries
W.-J. Kwak, S.A. Freunberger, H. Kim, J. Park, T.T. Nguyen, H.-G. Jung, H.R. Byon, Y.-K. Sun, ACS Catalysis 9 (2019) 9914–9922.
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W.-J. Kwak, S.A. Freunberger, H. Kim, J. Park, T.T. Nguyen, H.-G. Jung, H.R. Byon, Y.-K. Sun, ACS Catalysis 9 (2019) 9914–9922.
2019 | Journal Article | IST-REx-ID: 7282 |

Interphase identity crisis
S.A. Freunberger, Nature Chemistry 11 (2019) 761–763.
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S.A. Freunberger, Nature Chemistry 11 (2019) 761–763.
2019 | Journal Article | IST-REx-ID: 7283 |

Thousands of cycles
Y.K. Petit, S.A. Freunberger, Nature Materials 18 (2019) 301–302.
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Y.K. Petit, S.A. Freunberger, Nature Materials 18 (2019) 301–302.
2019 | Journal Article | IST-REx-ID: 7284 |

Li-O2 cell-scale energy densities
C. Prehal, S.A. Freunberger, Joule 3 (2019) 321–323.
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C. Prehal, S.A. Freunberger, Joule 3 (2019) 321–323.
2019 | Journal Article | IST-REx-ID: 73 |

On the geometry of geodesics in discrete optimal transport
M. Erbar, J. Maas, M. Wirth, Calculus of Variations and Partial Differential Equations 58 (2019).
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| arXiv
M. Erbar, J. Maas, M. Wirth, Calculus of Variations and Partial Differential Equations 58 (2019).
2019 | Journal Article | IST-REx-ID: 7340 |

Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR
N.P. Amin-Wetzel, L. Neidhardt, Y. Yan, M.P. Mayer, D. Ron, ELife 8 (2019).
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N.P. Amin-Wetzel, L. Neidhardt, Y. Yan, M.P. Mayer, D. Ron, ELife 8 (2019).
2019 | Preprint | IST-REx-ID: 7358 |

TGFβ superfamily signaling regulates the state of human stem cell pluripotency and competency to create telencephalic organoids
M. Watanabe, J.R. Haney, N. Vishlaghi, F. Turcios, J.E. Buth, W. Gu, A.J. Collier, O. Miranda, D. Chen, S. Sabri, A.T. Clark, K. Plath, H.R. Christofk, M.J. Gandal, B.G. Novitch, BioRxiv (2019).
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M. Watanabe, J.R. Haney, N. Vishlaghi, F. Turcios, J.E. Buth, W. Gu, A.J. Collier, O. Miranda, D. Chen, S. Sabri, A.T. Clark, K. Plath, H.R. Christofk, M.J. Gandal, B.G. Novitch, BioRxiv (2019).
2019 | Journal Article | IST-REx-ID: 7391 |

Electron microscopic detection of single membrane proteins by a specific chemical labeling
S. Tabata, M. Jevtic, N. Kurashige, H. Fuchida, M. Kido, K. Tani, N. Zenmyo, S. Uchinomiya, H. Harada, M. Itakura, I. Hamachi, R. Shigemoto, A. Ojida, IScience 22 (2019) 256–268.
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S. Tabata, M. Jevtic, N. Kurashige, H. Fuchida, M. Kido, K. Tani, N. Zenmyo, S. Uchinomiya, H. Harada, M. Itakura, I. Hamachi, R. Shigemoto, A. Ojida, IScience 22 (2019) 256–268.
2019 | Journal Article | IST-REx-ID: 7393 |

Genomic architecture of parallel ecological divergence: Beyond a single environmental contrast
H.E. Morales, R. Faria, K. Johannesson, T. Larsson, M. Panova, A.M. Westram, R.K. Butlin, Science Advances 5 (2019).
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H.E. Morales, R. Faria, K. Johannesson, T. Larsson, M. Panova, A.M. Westram, R.K. Butlin, Science Advances 5 (2019).
2019 | Journal Article | IST-REx-ID: 7394
Editorial overview: Cell biology in the era of omics?
E. Benková, Y. Dagdas, Current Opinion in Plant Biology 52 (2019) A1–A2.
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| PubMed | Europe PMC
E. Benková, Y. Dagdas, Current Opinion in Plant Biology 52 (2019) A1–A2.
2019 | Journal Article | IST-REx-ID: 7395 |

Structures of respiratory supercomplex I+III2 reveal functional and conformational crosstalk
J.A. Letts, K. Fiedorczuk, G. Degliesposti, M. Skehel, L.A. Sazanov, Molecular Cell 75 (2019) 1131–1146.e6.
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J.A. Letts, K. Fiedorczuk, G. Degliesposti, M. Skehel, L.A. Sazanov, Molecular Cell 75 (2019) 1131–1146.e6.
2019 | Journal Article | IST-REx-ID: 7396 |

Quantum control of molecular rotation
C.P. Koch, M. Lemeshko, D. Sugny, Reviews of Modern Physics 91 (2019).
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C.P. Koch, M. Lemeshko, D. Sugny, Reviews of Modern Physics 91 (2019).
2019 | Journal Article | IST-REx-ID: 7397 |

Dynamics of viscoelastic pipe flow at low Reynolds numbers in the maximum drag reduction limit
J.M. Lopez Alonso, G.H. Choueiri, B. Hof, Journal of Fluid Mechanics 874 (2019) 699–719.
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J.M. Lopez Alonso, G.H. Choueiri, B. Hof, Journal of Fluid Mechanics 874 (2019) 699–719.
2019 | Journal Article | IST-REx-ID: 7398 |

A comparison of the transport kinetics of glycine transporter 1 and glycine transporter 2
F.A. Erdem, M. Ilic, P. Koppensteiner, J. Gołacki, G. Lubec, M. Freissmuth, W. Sandtner, The Journal of General Physiology 151 (2019) 1035–1050.
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F.A. Erdem, M. Ilic, P. Koppensteiner, J. Gołacki, G. Lubec, M. Freissmuth, W. Sandtner, The Journal of General Physiology 151 (2019) 1035–1050.
2019 | Journal Article | IST-REx-ID: 7399 |

The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes
D. Andergassen, M. Muckenhuber, P.C. Bammer, T.M. Kulinski, H.-C. Theussl, T. Shimizu, J.M. Penninger, F. Pauler, Q.J. Hudson, PLOS Genetics 15 (2019).
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D. Andergassen, M. Muckenhuber, P.C. Bammer, T.M. Kulinski, H.-C. Theussl, T. Shimizu, J.M. Penninger, F. Pauler, Q.J. Hudson, PLOS Genetics 15 (2019).
2019 | Journal Article | IST-REx-ID: 7400 |

Early sex-chromosome evolution in the diploid dioecious plant Mercurialis annua
P. Veltsos, K.E. Ridout, M.A. Toups, S.C. González-Martínez, A. Muyle, O. Emery, P. Rastas, V. Hudzieczek, R. Hobza, B. Vyskot, G.A.B. Marais, D.A. Filatov, J.R. Pannell, Genetics 212 (2019) 815–835.
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P. Veltsos, K.E. Ridout, M.A. Toups, S.C. González-Martínez, A. Muyle, O. Emery, P. Rastas, V. Hudzieczek, R. Hobza, B. Vyskot, G.A.B. Marais, D.A. Filatov, J.R. Pannell, Genetics 212 (2019) 815–835.
2019 | Conference Paper | IST-REx-ID: 7401 |

Z_2-Genus of graphs and minimum rank of partial symmetric matrices
R. Fulek, J. Kyncl, in:, 35th International Symposium on Computational Geometry (SoCG 2019), Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019.
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| arXiv
R. Fulek, J. Kyncl, in:, 35th International Symposium on Computational Geometry (SoCG 2019), Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019.
2019 | Conference Paper | IST-REx-ID: 7402 |

Graph planning with expected finite horizon
K. Chatterjee, L. Doyen, in:, 34th Annual ACM/IEEE Symposium on Logic in Computer Science, IEEE, 2019, pp. 1–13.
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| arXiv
K. Chatterjee, L. Doyen, in:, 34th Annual ACM/IEEE Symposium on Logic in Computer Science, IEEE, 2019, pp. 1–13.
2019 | Journal Article | IST-REx-ID: 7404 |

Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo
T. Stürner, A. Tatarnikova, J. Müller, B. Schaffran, H. Cuntz, Y. Zhang, M. Nemethova, S. Bogdan, V. Small, G. Tavosanis, Development 146 (2019).
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T. Stürner, A. Tatarnikova, J. Müller, B. Schaffran, H. Cuntz, Y. Zhang, M. Nemethova, S. Bogdan, V. Small, G. Tavosanis, Development 146 (2019).
2019 | Journal Article | IST-REx-ID: 7405 |

NetPyNE, a tool for data-driven multiscale modeling of brain circuits
S. Dura-Bernal, B. Suter, P. Gleeson, M. Cantarelli, A. Quintana, F. Rodriguez, D.J. Kedziora, G.L. Chadderdon, C.C. Kerr, S.A. Neymotin, R.A. McDougal, M. Hines, G.M. Shepherd, W.W. Lytton, ELife 8 (2019).
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S. Dura-Bernal, B. Suter, P. Gleeson, M. Cantarelli, A. Quintana, F. Rodriguez, D.J. Kedziora, G.L. Chadderdon, C.C. Kerr, S.A. Neymotin, R.A. McDougal, M. Hines, G.M. Shepherd, W.W. Lytton, ELife 8 (2019).
2019 | Journal Article | IST-REx-ID: 7406
Isolation of synaptic vesicles from genetically engineered cultured neurons
C. Mckenzie, M. Spanova, A.J. Johnson, S. Kainrath, V. Zheden, H.H. Sitte, H.L. Janovjak, Journal of Neuroscience Methods 312 (2019) 114–121.
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| PubMed | Europe PMC
C. Mckenzie, M. Spanova, A.J. Johnson, S. Kainrath, V. Zheden, H.H. Sitte, H.L. Janovjak, Journal of Neuroscience Methods 312 (2019) 114–121.
2019 | Book Chapter | IST-REx-ID: 7410
Mechanisms of zebrafish epiboly: A current view
A.E.E. Bruce, C.-P.J. Heisenberg, in:, L. Solnica-Krezel (Ed.), Gastrulation: From Embryonic Pattern to Form, Elsevier, 2019, pp. 319–341.
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A.E.E. Bruce, C.-P.J. Heisenberg, in:, L. Solnica-Krezel (Ed.), Gastrulation: From Embryonic Pattern to Form, Elsevier, 2019, pp. 319–341.
2019 | Conference Paper | IST-REx-ID: 7411 |

Reversible proofs of sequential work
H.M. Abusalah, C. Kamath Hosdurg, K. Klein, K.Z. Pietrzak, M. Walter, in:, Advances in Cryptology – EUROCRYPT 2019, Springer International Publishing, 2019, pp. 277–291.
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H.M. Abusalah, C. Kamath Hosdurg, K. Klein, K.Z. Pietrzak, M. Walter, in:, Advances in Cryptology – EUROCRYPT 2019, Springer International Publishing, 2019, pp. 277–291.
2019 | Journal Article | IST-REx-ID: 7412 |

A local lemma for focused stochastical algorithms
D. Achlioptas, F. Iliopoulos, V. Kolmogorov, SIAM Journal on Computing 48 (2019) 1583–1602.
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| arXiv
D. Achlioptas, F. Iliopoulos, V. Kolmogorov, SIAM Journal on Computing 48 (2019) 1583–1602.
2019 | Journal Article | IST-REx-ID: 7413 |

Bogoliubov theory in the Gross–Pitaevskii limit
C. Boccato, C. Brennecke, S. Cenatiempo, B. Schlein, Acta Mathematica 222 (2019) 219–335.
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| arXiv
C. Boccato, C. Brennecke, S. Cenatiempo, B. Schlein, Acta Mathematica 222 (2019) 219–335.
2019 | Journal Article | IST-REx-ID: 7414
S.16.03 A homozygous missense mutation in SLC7A5 leads to autism spectrum disorder and microcephaly
L. Knaus, D.-C. Tarlungeanu, G. Novarino, European Neuropsychopharmacology 29 (2019) S11.
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L. Knaus, D.-C. Tarlungeanu, G. Novarino, European Neuropsychopharmacology 29 (2019) S11.
2019 | Journal Article | IST-REx-ID: 7415
S.16.05 Illuminating the role of the e3 ubiquitin ligase cullin3 in brain development and autism
J. Morandell, A. Nicolas, L.A. Schwarz, G. Novarino, European Neuropsychopharmacology 29 (2019) S11–S12.
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J. Morandell, A. Nicolas, L.A. Schwarz, G. Novarino, European Neuropsychopharmacology 29 (2019) S11–S12.