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96 Publications


2019 | Journal Article | IST-REx-ID: 7105 | OA
Persistent and polarized global actin flow is essential for directionality during cell migration
L. Yolland, M. Burki, S. Marcotti, A. Luchici, F.N. Kenny, J.R. Davis, E. Serna-Morales, J. Müller, M.K. Sixt, A. Davidson, W. Wood, L.J. Schumacher, R.G. Endres, M. Miodownik, B.M. Stramer, Nature Cell Biology 21 (2019) 1370–1381.
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2019 | Journal Article | IST-REx-ID: 6824
Patrolling the vascular borders: Platelets in immunity to infection and cancer
F.R. Gärtner, S. Massberg, Nature Reviews Immunology 19 (2019) 747–760.
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2019 | Thesis | IST-REx-ID: 6891 | OA
The implication of cytoskeletal dynamics on leukocyte migration
A. Kopf, The Implication of Cytoskeletal Dynamics on Leukocyte Migration, IST Austria, 2019.
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2019 | Thesis | IST-REx-ID: 6947 | OA
Lymph node mechanics: Deciphering the interplay between stroma contractility, morphology and lymphocyte trafficking
F.P. Assen, Lymph Node Mechanics: Deciphering the Interplay between Stroma Contractility, Morphology and Lymphocyte Trafficking, IST Austria, 2019.
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2019 | Journal Article | IST-REx-ID: 6328 | OA
Nuclear positioning facilitates amoeboid migration along the path of least resistance
J. Renkawitz, A. Kopf, J.A. Stopp, I. de Vries, M.K. Driscoll, J. Merrin, R. Hauschild, E.S. Welf, G. Danuser, R. Fiolka, M.K. Sixt, Nature 568 (2019) 546–550.
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2019 | Journal Article | IST-REx-ID: 6877
The neural crest pitches in to remove apoptotic debris
A. Kopf, M.K. Sixt, Cell 179 (2019) 51–53.
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2018 | Journal Article | IST-REx-ID: 437 | OA
Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration
A.F. Leithner, J. Renkawitz, I. de Vries, R. Hauschild, H. Haecker, M.K. Sixt, European Journal of Immunology 48 (2018) 1074–1077.
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2018 | Journal Article | IST-REx-ID: 5672 | OA
IgM's exit route
A. REVERSAT, M.K. Sixt, Journal of Experimental Medicine 215 (2018) 2959–2961.
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2018 | Journal Article | IST-REx-ID: 5858 | OA
Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data
S. Hross, F.J. Theis, M.K. Sixt, J. Hasenauer, Journal of the Royal Society Interface 15 (2018).
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2018 | Journal Article | IST-REx-ID: 5861 | OA
The cell sets the tone
J.H. Alanko, M.K. Sixt, ELife 7 (2018).
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2018 | Journal Article | IST-REx-ID: 5984 | OA
Optical functionalization of human class A orphan G-protein-coupled receptors
M. Morri, I. Sanchez-Romero, A.-M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz, H.L. Janovjak, Nature Communications 9 (2018).
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2018 | Journal Article | IST-REx-ID: 5992 | OA
On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility
S. Dolati, F. Kage, J. Mueller, M. Müsken, M. Kirchner, G. Dittmar, M.K. Sixt, K. Rottner, M. Falcke, Molecular Biology of the Cell 29 (2018) 2674–2686.
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2018 | Journal Article | IST-REx-ID: 275 | OA
Lymphatic exosomes promote dendritic cell migration along guidance cues
M. Brown, L. Johnson, D. Leone, P. Májek, K. Vaahtomeri, D. Senfter, N. Bukosza, H. Schachner, G. Asfour, B. Langer, R. Hauschild, K. Parapatics, Y. Hong, K. Bennett, R. Kain, M. Detmar, M.K. Sixt, D. Jackson, D. Kerjaschki, Journal of Cell Biology 217 (2018) 2205–2221.
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2018 | Journal Article | IST-REx-ID: 276 | OA
Nano-scale microfluidics to study 3D chemotaxis at the single cell level
C. Frick, P. Dettinger, J. Renkawitz, A. Jauch, C. Berger, M. Recher, T. Schroeder, M. Mehling, PLoS One 13 (2018).
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2018 | Journal Article | IST-REx-ID: 6354 | OA
Platelet migration and bacterial trapping assay under flow
S. Fan, M. Lorenz, S. Massberg, F.R. Gärtner, Bio-Protocol 8 (2018).
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2018 | Journal Article | IST-REx-ID: 6497 | OA
The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+T cells
F. Moalli, X. Ficht, P. Germann, M. Vladymyrov, B. Stolp, I. de Vries, R. Lyck, J. Balmer, A. Fiocchi, M. Kreutzfeldt, D. Merkler, M. Iannacone, A. Ariga, M.H. Stoffel, J. Sharpe, M. Bähler, M.K. Sixt, A. Diz-Muñoz, J.V. Stein, The Journal of Experimental Medicine 2015 (2018) 1869–1890.
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2018 | Book Chapter | IST-REx-ID: 153
Micro-engineered “pillar forests” to study cell migration in complex but controlled 3D environments
J. Renkawitz, A. Reversat, A.F. Leithner, J. Merrin, M.K. Sixt, in:, Methods in Cell Biology, Academic Press, 2018, pp. 79–91.
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2018 | Journal Article | IST-REx-ID: 318 | OA
A fat lot of good for wound healing
A.M. Casano, M.K. Sixt, Developmental Cell 44 (2018) 405–406.
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2018 | Thesis | IST-REx-ID: 323 | OA
Branched actin networks in dendritic cell biology
A.F. Leithner, Branched Actin Networks in Dendritic Cell Biology, IST Austria, 2018.
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2018 | Journal Article | IST-REx-ID: 308 | OA
Drosophila TNF modulates tissue tension in the embryo to facilitate macrophage invasive migration
A. Ratheesh, J. Biebl, M. Smutny, J. Veselá, E. Papusheva, G. Krens, W. Kaufmann, A. György, A.M. Casano, D.E. Siekhaus, Developmental Cell 45 (2018) 331–346.
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2018 | Journal Article | IST-REx-ID: 15 | OA
Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells
M. Hons, A. Kopf, R. Hauschild, A.F. Leithner, F.R. Gärtner, J. Abe, J. Renkawitz, J. Stein, M.K. Sixt, Nature Immunology 19 (2018) 606–616.
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2018 | Journal Article | IST-REx-ID: 402 | OA
Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice
M. Brown, F.P. Assen, A.F. Leithner, J. Abe, H. Schachner, G. Asfour, Z. Bagó Horváth, J. Stein, P. Uhrin, M.K. Sixt, D. Kerjaschki, Science 359 (2018) 1408–1411.
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2017 | Journal Article | IST-REx-ID: 727
Load adaptation of lamellipodial actin networks
J. Mueller, G. Szep, M. Nemethova, I. De Vries, A. Lieber, C. Winkler, K. Kruse, J. Small, C. Schmeiser, K. Keren, R. Hauschild, M.K. Sixt, Cell 171 (2017) 188–200.
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2017 | Research Data | IST-REx-ID: 5567 | OA
Immunological synapse DC-Tcells
A.F. Leithner, Immunological Synapse DC-Tcells, IST Austria, 2017.
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2017 | Journal Article | IST-REx-ID: 569 | OA
Cytokinesis in vertebrate cells initiates by contraction of an equatorial actomyosin network composed of randomly oriented filaments
F. Spira, S. Cuylen Haering, S. Mehta, M. Samwer, A. REVERSAT, A. Verma, R. Oldenbourg, M.K. Sixt, D. Gerlich, ELife 6 (2017).
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2017 | Journal Article | IST-REx-ID: 571
Migrating platelets are mechano scavengers that collect and bundle bacteria
F.R. Gärtner, Z. Ahmad, G. Rosenberger, S. Fan, L. Nicolai, B. Busch, G. Yavuz, M. Luckner, H. Ishikawa Ankerhold, R. Hennel, A. Benechet, M. Lorenz, S. Chandraratne, I. Schubert, S. Helmer, B. Striednig, K. Stark, M. Janko, R. Böttcher, A. Verschoor, C. Leon, C. Gachet, T. Gudermann, M. Mederos Y Schnitzler, Z. Pincus, M. Iannacone, R. Haas, G. Wanner, K. Lauber, M.K. Sixt, S. Massberg, Cell Press 171 (2017) 1368–1382.
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2017 | Journal Article | IST-REx-ID: 659 | OA
FMNL formins boost lamellipodial force generation
F. Kage, M. Winterhoff, V. Dimchev, J. Müller, T. Thalheim, A. Freise, S. Brühmann, J. Kollasser, J. Block, G.A. Dimchev, M. Geyer, H. Schnittler, C. Brakebusch, T. Stradal, M. Carlier, M.K. Sixt, J. Käs, J. Faix, K. Rottner, Nature Communications 8 (2017).
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2017 | Journal Article | IST-REx-ID: 668 | OA
Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion
M. Horsthemke, A. Bachg, K. Groll, S. Moyzio, B. Müther, S. Hemkemeyer, R. Wedlich Söldner, M.K. Sixt, S. Tacke, M. Bähler, P. Hanley, Journal of Biological Chemistry 292 (2017) 7258–7273.
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2017 | Journal Article | IST-REx-ID: 672 | OA
Locally triggered release of the chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia
K. Vaahtomeri, M. Brown, R. Hauschild, I. de Vries, A.F. Leithner, M. Mehling, W. Kaufmann, M.K. Sixt, Cell Reports 19 (2017) 902–909.
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2017 | Journal Article | IST-REx-ID: 674
Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6
J. Schwarz, V. Bierbaum, K. Vaahtomeri, R. Hauschild, M. Brown, I. De Vries, A.F. Leithner, A. Reversat, J. Merrin, T. Tarrant, T. Bollenbach, M.K. Sixt, Current Biology 27 (2017) 1314–1325.
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2017 | Journal Article | IST-REx-ID: 677 | OA
The INO80 complex removes H2A.Z to promote presynaptic filament formation during homologous recombination
C. Lademann, J. Renkawitz, B. Pfander, S. Jentsch, Cell Reports 19 (2017) 1294–1303.
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2017 | Journal Article | IST-REx-ID: 679 | OA
The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection
F. Ebner, V. Sedlyarov, S. Tasciyan, M. Ivin, F. Kratochvill, N. Gratz, L. Kenner, A. Villunger, M.K. Sixt, P. Kovarik, The Journal of Clinical Investigation 127 (2017) 2051–2065.
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2017 | Journal Article | IST-REx-ID: 694 | OA
A dual phenotype of MDA MB 468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity
A. Veß, U. Blache, L. Leitner, A. Kurz, A. Ehrenpfordt, M.K. Sixt, G. Posern, Journal of Cell Science 130 (2017) 2172–2184.
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2017 | Journal Article | IST-REx-ID: 1161
Cell migration: Making the waves
J. Müller, M.K. Sixt, Current Biology 27 (2017) R24–R25.
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2017 | Journal Article | IST-REx-ID: 664
The dynamic cytokine niche
F.P. Assen, M.K. Sixt, Immunity 46 (2017) 519–520.
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2016 | Journal Article | IST-REx-ID: 1597
Quantitative analysis of dendritic cell haptotaxis
J. Schwarz, M.K. Sixt, Methods in Enzymology 570 (2016) 567–581.
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2016 | Journal Article | IST-REx-ID: 1599 | OA
Polysialylation controls dendritic cell trafficking by regulating chemokine recognition
E. Kiermaier, C. Moussion, C. Veldkamp, R. Gerardy  Schahn, I. de Vries, L. Williams, G. Chaffee, A. Phillips, F. Freiberger, R. Imre, D. Taleski, R. Payne, A. Braun, R. Förster, K. Mechtler, M. Mühlenhoff, B. Volkman, M.K. Sixt, Science 351 (2016) 186–190.
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2016 | Journal Article | IST-REx-ID: 1201
Formin’ a nuclear protection
J. Renkawitz, M.K. Sixt, Cell 167 (2016) 1448–1449.
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2016 | Journal Article | IST-REx-ID: 1217
Efficient T-cell priming and activation requires signaling through prostaglandin E2 (EP) receptors
V. Sreeramkumar, M. Hons, C. Punzón, J. Stein, D. Sancho, M. Fresno Forcelledo, N. Cuesta, Immunology and Cell Biology 94 (2016) 39–51.
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2016 | Journal Article | IST-REx-ID: 1285
Focal adhesion-independent cell migration
E. Paluch, I. Aspalter, M.K. Sixt, Annual Review of Cell and Developmental Biology 32 (2016) 469–490.
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2016 | Journal Article | IST-REx-ID: 1321 | OA
Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes
A.F. Leithner, A. Eichner, J. Müller, A. REVERSAT, M. Brown, J. Schwarz, J. Merrin, D. De Gorter, F.K. Schur, J. Bayerl, I. de Vries, S. Wieser, R. Hauschild, F. Lai, M. Moser, D. Kerjaschki, K. Rottner, V. Small, T. Stradal, M.K. Sixt, Nature Cell Biology 18 (2016) 1253–1259.
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2016 | Journal Article | IST-REx-ID: 1490 | OA
Intralymphatic CCL21 promotes tissue egress of dendritic cells through afferent lymphatic vessels
E. Russo, A. Teijeira, K. Vaahtomeri, A. Willrodt, J. Bloch, M. Nitschké, L. Santambrogio, D. Kerjaschki, M.K. Sixt, C. Halin, Cell Reports 14 (2016) 1723–1734.
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2016 | Thesis | IST-REx-ID: 1129
Quantitative analysis of haptotactic cell migration
J. Schwarz, Quantitative Analysis of Haptotactic Cell Migration, IST Austria, 2016.
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2016 | Journal Article | IST-REx-ID: 1137 | OA
RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics
E. Salzer, D. Çaǧdaş, M. Hons, E. Mace, W. Garncarz, O. Petronczki, R. Platzer, L. Pfajfer, I. Bilic, S. Ban, K. Willmann, M. Mukherjee, V. Supper, H. Hsu, P. Banerjee, P. Sinha, F. Mcclanahan, G. Zlabinger, W. Pickl, J. Gribben, H. Stockinger, K. Bennett, J. Huppa, L. Dupré, Ö. Sanal, U. Jäger, M.K. Sixt, I. Tezcan, J. Orange, K. Boztug, Nature Immunology 17 (2016) 1352–1360.
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2016 | Journal Article | IST-REx-ID: 1142 | OA
Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions
R. Martins, J. Maier, A. Gorki, K. Huber, O. Sharif, P. Starkl, S. Saluzzo, F. Quattrone, R. Gawish, K. Lakovits, M. Aichinger, B. Radic Sarikas, C. Lardeau, A. Hladik, A. Korosec, M. Brown, K. Vaahtomeri, M. Duggan, D. Kerjaschki, H. Esterbauer, J. Colinge, S. Eisenbarth, T. Decker, K. Bennett, S. Kubicek, M.K. Sixt, G. Superti Furga, S. Knapp, Nature Immunology 17 (2016) 1361–1372.
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2016 | Journal Article | IST-REx-ID: 1150
A Radical Break Restraining Neutrophil Migration
J. Renkawitz, M.K. Sixt, Developmental Cell 38 (2016) 448–450.
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2016 | Journal Article | IST-REx-ID: 1154 | OA
A microfluidic device for measuring cell migration towards substrate bound and soluble chemokine gradients
J. Schwarz, V. Bierbaum, J. Merrin, T. Frank, R. Hauschild, M.T. Bollenbach, S. Tay, M.K. Sixt, M. Mehling, Scientific Reports 6 (2016).
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2015 | Journal Article | IST-REx-ID: 477
The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells
K. Holst, D. Guseva, S. Schindler, M.K. Sixt, A. Braun, H. Chopra, O. Pabst, E. Ponimaskin, Journal of Cell Science 128 (2015) 2866–2880.
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2015 | Journal Article | IST-REx-ID: 1553
Actin flows mediate a universal coupling between cell speed and cell persistence
P. Maiuri, J. Rupprecht, S. Wieser, V. Ruprecht, O. Bénichou, N. Carpi, M. Coppey, S. De Beco, N. Gov, C.-P.J. Heisenberg, C. Lage Crespo, F. Lautenschlaeger, M. Le Berre, A. Lennon Duménil, M. Raab, H. Thiam, M. Piel, M.K. Sixt, R. Voituriez, Cell 161 (2015) 374–386.
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2015 | Journal Article | IST-REx-ID: 1560
The lymph node filter revealed
M. Hons, M.K. Sixt, Nature Immunology 16 (2015) 338–340.
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