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48 Publications


2024 | Journal Article | IST-REx-ID: 15323
SCAF1 drives the compositional diversity of mammalian respirasomes
I. Vercellino, L.A. Sazanov, Nature Structural and Molecular Biology (2024).
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2023 | Journal Article | IST-REx-ID: 12757 | OA
From the 'black box' to 'domino effect' mechanism: What have we learned from the structures of respiratory complex I
L.A. Sazanov, The Biochemical Journal 480 (2023) 319–333.
[Published Version] View | DOI | Download Published Version (ext.) | WoS | PubMed | Europe PMC
 

2023 | Journal Article | IST-REx-ID: 13232 | OA
Design and immunogenicity of SARS-CoV-2 DNA vaccine encoding RBD-PVXCP fusion protein
D. Dormeshkin, M. Katsin, M. Stegantseva, S. Golenchenko, M. Shapira, S. Dubovik, D. Lutskovich, A. Kavaleuski, A. Meleshko, Vaccines 11 (2023).
[Published Version] View | Files available | DOI | WoS
 

2023 | Thesis | IST-REx-ID: 12781
Structural and mechanistic study of bacterial complex I and its cyanobacterial ortholog
V. Kravchuk, Structural and Mechanistic Study of Bacterial Complex I and Its Cyanobacterial Ortholog, Institute of Science and Technology Austria, 2023.
[Published Version] View | Files available | DOI
 

2023 | Journal Article | IST-REx-ID: 14040 | OA
The Ycf48 accessory factor occupies the site of the oxygen-evolving manganese cluster during photosystem II biogenesis
Z. Zhao, I. Vercellino, J. Knoppová, R. Sobotka, J.W. Murray, P.J. Nixon, L.A. Sazanov, J. Komenda, Nature Communications 14 (2023).
[Published Version] View | Files available | DOI | WoS
 

2022 | Journal Article | IST-REx-ID: 10182
The assembly, regulation and function of the mitochondrial respiratory chain
I. Vercellino, L.A. Sazanov, Nature Reviews Molecular Cell Biology 23 (2022) 141–161.
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2022 | Journal Article | IST-REx-ID: 11167 | OA
Structure of respiratory complex I – An emerging blueprint for the mechanism
D. Kampjut, L.A. Sazanov, Current Opinion in Structural Biology 74 (2022).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2022 | Journal Article | IST-REx-ID: 11551 | OA
Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit
D. Molina-Granada, E. González-Vioque, M.G. Dibley, R. Cabrera-Pérez, A. Vallbona-Garcia, J. Torres-Torronteras, L.A. Sazanov, M.T. Ryan, Y. Cámara, R. Martí, Communications Biology 5 (2022).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2022 | Journal Article | IST-REx-ID: 11648 | OA
Structures of multisubunit membrane complexes with the CRYO ARM 200
C. Gerle, J. Kishikawa, T. Yamaguchi, A. Nakanishi, M.O. Çoruh, F. Makino, T. Miyata, A. Kawamoto, K. Yokoyama, K. Namba, G. Kurisu, T. Kato, Microscopy 71 (2022) 249–261.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2022 | Journal Article | IST-REx-ID: 12138 | OA
A universal coupling mechanism of respiratory complex I
V. Kravchuk, O. Petrova, D. Kampjut, A. Wojciechowska-Bason, Z. Breese, L.A. Sazanov, Nature 609 (2022) 808–814.
[Submitted Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2022 | Journal Article | IST-REx-ID: 12252 | OA
Isolation of an escape-resistant SARS-CoV-2 neutralizing nanobody from a novel synthetic nanobody library
D. Dormeshkin, M. Shapira, S. Dubovik, A. Kavaleuski, M. Katsin, A. Migas, A. Meleshko, S. Semyonov, Frontiers in Immunology 13 (2022).
[Published Version] View | Files available | DOI | WoS
 

2022 | Journal Article | IST-REx-ID: 12282
Operation STEM fatale – how an equity, diversity and inclusion initiative has brought us to reflect on the current challenges in cell biology and science as a whole
N. Amberg, M.A. Stouffer, I. Vercellino, Journal of Cell Science 135 (2022).
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2022 | Journal Article | IST-REx-ID: 10945 | OA
pH-dependent coloring of combination effect pigments with anthocyanins from Brassica oleracea var. capitata F. rubra
M.O. Çoruh, G. Gündüz, Ü. Çolak, B. Maviş, Colorants 1 (2022) 149–164.
[Published Version] View | Files available | DOI
 

2022 | Journal Article | IST-REx-ID: 11462
Combining of synthetic VHH and immune scFv libraries for pregnancy-associated glycoproteins ELISA development
D. Dormeshkin, M. Shapira, A. Karputs, A. Kavaleuski, I. Kuzminski, E. Stepanova, A. Gilep, Applied Microbiology and Biotechnology 106 (2022) 5093–5103.
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2021 | Journal Article | IST-REx-ID: 8993 | OA
Naphthylphthalamic acid associates with and inhibits PIN auxin transporters
L. Abas, M. Kolb, J. Stadlmann, D.P. Janacek, K. Lukic, C. Schwechheimer, L.A. Sazanov, L. Mach, J. Friml, U.Z. Hammes, PNAS 118 (2021).
[Published Version] View | Files available | DOI | Download Published Version (ext.) | WoS | PubMed | Europe PMC
 

2021 | Journal Article | IST-REx-ID: 9205 | OA
Cryo-EM grid optimization for membrane proteins
D. Kampjut, J. Steiner, L.A. Sazanov, IScience 24 (2021).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2021 | Journal Article | IST-REx-ID: 10146
Structure and assembly of the mammalian mitochondrial supercomplex CIII2CIV
I. Vercellino, L.A. Sazanov, Nature 598 (2021) 364–367.
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2021 | Journal Article | IST-REx-ID: 10310 | OA
Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster
M.O. Çoruh, A. Frank, H. Tanaka, A. Kawamoto, E. El-Mohsnawy, T. Kato, K. Namba, C. Gerle, M.M. Nowaczyk, G. Kurisu, Communications Biology 4 (2021).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2021 | Journal Article | IST-REx-ID: 15274 | OA
Cysteine mutants of the major facilitator superfamily-type transporter CcoA provide insight into copper import
B. Khalfaoui-Hassani, P.I. Trasnea, S. Steimle, H.-G. Koch, F. Daldal, MBio 12 (2021).
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 

2020 | Journal Article | IST-REx-ID: 7788 | OA
NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4−/− mice and Leigh syndrome patients: A stabilizing role for NDUFAF2
M.J.W. Adjobo-Hermans, R. De Haas, P.H.G.M. Willems, A. Wojtala, S.E. Van Emst-De Vries, J.A. Wagenaars, M. Van Den Brand, R.J. Rodenburg, J.A.M. Smeitink, L.G. Nijtmans, L.A. Sazanov, M.R. Wieckowski, W.J.H. Koopman, Biochimica et Biophysica Acta - Bioenergetics 1861 (2020).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2020 | Journal Article | IST-REx-ID: 8040
Charge transfer and chemo-mechanical coupling in respiratory complex I
C. Gupta, U. Khaniya, C.K. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, Journal of the American Chemical Society 142 (2020) 9220–9230.
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2020 | Research Data Reference | IST-REx-ID: 9326 | OA
Charge transfer and chemo-mechanical coupling in respiratory complex I
C. Gupta, U. Khaniya, C. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020).
[Published Version] View | Files available | DOI | Download Published Version (ext.)
 

2020 | Research Data Reference | IST-REx-ID: 9713
Supporting information
C. Gupta, U. Khaniya, C.K. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020).
[Published Version] View | Files available | DOI
 

2020 | Research Data Reference | IST-REx-ID: 9878
Movies
C. Gupta, U. Khaniya, C.K. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020).
[Published Version] View | Files available | DOI
 

2020 | Journal Article | IST-REx-ID: 8318 | OA
Key role of quinone in the mechanism of respiratory complex I
J. Gutierrez-Fernandez, K. Kaszuba, G.S. Minhas, R. Baradaran, M. Tambalo, D.T. Gallagher, L.A. Sazanov, Nature Communications 11 (2020).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2020 | Journal Article | IST-REx-ID: 8579 | OA
Cu homeostasis in bacteria: The ins and outs
A. Andrei, Y. Öztürk, B. Khalfaoui-Hassani, J. Rauch, D. Marckmann, P.I. Trasnea, F. Daldal, H.-G. Koch, Membranes 10 (2020).
[Published Version] View | Files available | DOI | WoS
 

2020 | Journal Article | IST-REx-ID: 8581
Cryo-EM structure of the entire mammalian F-type ATP synthase
G. Pinke, L. Zhou, L.A. Sazanov, Nature Structural and Molecular Biology 27 (2020) 1077–1085.
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2020 | Journal Article | IST-REx-ID: 8737 | OA
The coupling mechanism of mammalian respiratory complex I
D. Kampjut, L.A. Sazanov, Science 370 (2020).
[Submitted Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2020 | Thesis | IST-REx-ID: 8353 | OA
Biochemical and structural investigation of the Mrp antiporter, an ancestor of complex I
J. Steiner, Biochemical and Structural Investigation of the Mrp Antiporter, an Ancestor of Complex I, Institute of Science and Technology Austria, 2020.
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2020 | Journal Article | IST-REx-ID: 8284 | OA
Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter
J. Steiner, L.A. Sazanov, ELife 9 (2020).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2020 | Thesis | IST-REx-ID: 8340 | OA
Molecular mechanisms of mitochondrial redox-coupled proton pumping enzymes
D. Kampjut, Molecular Mechanisms of Mitochondrial Redox-Coupled Proton Pumping Enzymes, Institute of Science and Technology Austria, 2020.
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2019 | Journal Article | IST-REx-ID: 6352 | OA
Protective properties of the cultured stem cell proteome studied in an animal model of acetaminophen-induced acute liver failure
A.A. Temnov, K.A. Rogov, A.N. Sklifas, E.V. Klychnikova, M. Hartl, K. Djinovic-Carugo, A. Charnagalov, Molecular Biology Reports (2019).
[Published Version] View | Files available | DOI | WoS
 

2019 | Journal Article | IST-REx-ID: 6859
Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase
L. Zhou, L.A. Sazanov, Science 365 (2019).
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2019 | Journal Article | IST-REx-ID: 6919 | OA
Structural basis of sterol recognition by human hedgehog receptor PTCH1
C. Qi, G.D. Minin, I. Vercellino, A. Wutz, V.M. Korkhov, Science Advances 5 (2019).
[Published Version] View | Files available | DOI | WoS
 

2019 | Journal Article | IST-REx-ID: 7395 | OA
Structures of respiratory supercomplex I+III2 reveal functional and conformational crosstalk
J.A. Letts, K. Fiedorczuk, G. Degliesposti, M. Skehel, L.A. Sazanov, Molecular Cell 75 (2019) 1131–1146.e6.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2019 | Journal Article | IST-REx-ID: 6848 | OA
Structure and mechanism of mitochondrial proton-translocating transhydrogenase
D. Kampjut, L.A. Sazanov, Nature 573 (2019) 291–295.
[Submitted Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2018 | Journal Article | IST-REx-ID: 152 | OA
Mammalian mitochondrial complex I structure and disease causing mutations
K. Fiedorczuk, L.A. Sazanov, Trends in Cell Biology 28 (2018) 835–867.
[Submitted Version] View | Files available | DOI | WoS
 

2017 | Book Chapter | IST-REx-ID: 444
Structure of respiratory complex I: “Minimal” bacterial and “de luxe” mammalian versions
L.A. Sazanov, in:, M. Wikström (Ed.), Mechanisms of Primary Energy Transduction in Biology , Royal Society of Chemistry, 2017, pp. 25–59.
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2017 | Journal Article | IST-REx-ID: 515 | OA
Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain
J.A. Letts, L.A. Sazanov, Nature Structural and Molecular Biology 24 (2017) 800–808.
[Submitted Version] View | Files available | DOI
 

2016 | Journal Article | IST-REx-ID: 1186 | OA
Modular architecture and unique teichoic acid recognition features of choline-binding protein L CbpL contributing to pneumococcal pathogenesis
J. Gutierrez-Fernandez, M. Saleh, M. Alcorlo, A. Gómez Mejóa, D. Pantoja Uceda, M. Treviño, F. Vob, M. Abdullah, S. Galán Bartual, J. Seinen, P. Sánchez Murcia, F. Gago, M. Bruix, S. Hammerschmidt, J. Hermoso, Scientific Reports 6 (2016).
[Published Version] View | Files available | DOI
 

2016 | Journal Article | IST-REx-ID: 1209 | OA
Purification of ovine respiratory complex i results in a highly active and stable preparation
J.A. Letts, G. Degliesposti, K. Fiedorczuk, M. Skehel, L.A. Sazanov, Journal of Biological Chemistry 291 (2016) 24657–24675.
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2016 | Journal Article | IST-REx-ID: 1226 | OA
Atomic structure of the entire mammalian mitochondrial complex i
K. Fiedorczuk, J.A. Letts, G. Degliesposti, K. Kaszuba, M. Skehel, L.A. Sazanov, Nature 538 (2016) 406–410.
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 

2016 | Journal Article | IST-REx-ID: 1232
The architecture of respiratory supercomplexes
J.A. Letts, K. Fiedorczuk, L.A. Sazanov, Nature 537 (2016) 644–648.
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2016 | Journal Article | IST-REx-ID: 1276 | OA
Atomistic determinants of co-enzyme Q reduction at the Qi-site of the cytochrome bc1 complex
P. Postila, K. Kaszuba, P. Kuleta, I. Vattulainen, M. Sarewicz, A. Osyczka, T. Róg, Scientific Reports 6 (2016).
[Published Version] View | Files available | DOI
 

2016 | Journal Article | IST-REx-ID: 1288
Reversible FMN dissociation from Escherichia coli respiratory complex I
P. Holt, R. Efremov, E. Nakamaru Ogiso, L.A. Sazanov, Biochimica et Biophysica Acta - Bioenergetics 1857 (2016) 1777–1785.
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2016 | Journal Article | IST-REx-ID: 1521
Structure of bacterial respiratory complex I
J. Berrisford, R. Baradaran, L.A. Sazanov, Biochimica et Biophysica Acta - Bioenergetics 1857 (2016) 892–901.
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2015 | Journal Article | IST-REx-ID: 1638
A giant molecular proton pump: structure and mechanism of respiratory complex I
L.A. Sazanov, Nature Reviews Molecular Cell Biology 16 (2015) 375–388.
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2015 | Journal Article | IST-REx-ID: 1683
Gaining mass: The structure of respiratory complex I-from bacterial towards mitochondrial versions
J.A. Letts, L.A. Sazanov, Current Opinion in Structural Biology 33 (2015) 135–145.
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