Fürst, Johannes ; Jakab, Martin ; König, Matthias A ; Ritter, Markus ; Gschwentner, Martin ; Rudzki, Jakob ; Danzl, Johannes G ; Mayer, Michael R ; Burtscher, Carmen M ; Schirmer, Johanna ; Maier, Brigitte ; Nairz, Manfred
Normal function of organs and cells is tightly linked to the cytoarchitecture. Control of the cell volume is therefore vital for the organism. A widely established strategy of cells to counteract swelling is the activation of chloride and potassium channels, which leads to a net efflux of salt followed by water - a process termed regulatory volume decrease. Since there is evidence for swelling-dependent chloride channels (IClswell) being activated also during pathological processes, the identification of the molecular entity underlying IClswell is of utmost importance. Several proteins are discussed as the channel forming IClswell, i.e. phospholemman, p-glycoprotein, CLC-3 and ICln. In this review we would like to focus on the properties of ICln, a protein cloned from a Madin Darby canine kidney (MDCK) cell library whose expression in Xenopus laevis oocytes resulted in a nucleotide sensitive, outwardly rectifying chloride current closely resembling the biophysical properties of IClswell.
Cellular Physiology and Biochemistry
329 - 334
Fürst J, Jakab M, König M, et al. Structure and function of the ion channel ICln. Cellular Physiology and Biochemistry. 2000;10(5-6):329-334. doi:10.1159/000016374
Fürst, J., Jakab, M., König, M., Ritter, M., Gschwentner, M., Rudzki, J., … Paulmichl, M. (2000). Structure and function of the ion channel ICln. Cellular Physiology and Biochemistry. S. Karger AG. https://doi.org/10.1159/000016374
Fürst, Johannes, Martin Jakab, Matthias König, Markus Ritter, Martin Gschwentner, Jakob Rudzki, Johannes Danzl, et al. “Structure and Function of the Ion Channel ICln.” Cellular Physiology and Biochemistry. S. Karger AG, 2000. https://doi.org/10.1159/000016374.
J. Fürst et al., “Structure and function of the ion channel ICln,” Cellular Physiology and Biochemistry, vol. 10, no. 5–6. S. Karger AG, pp. 329–334, 2000.
Fürst J, Jakab M, König M, Ritter M, Gschwentner M, Rudzki J, Danzl J, Mayer M, Burtscher C, Schirmer J, Maier B, Nairz M, Chwatal S, Paulmichl M. 2000. Structure and function of the ion channel ICln. Cellular Physiology and Biochemistry. 10(5–6), 329–334.
Fürst, Johannes, et al. “Structure and Function of the Ion Channel ICln.” Cellular Physiology and Biochemistry, vol. 10, no. 5–6, S. Karger AG, 2000, pp. 329–34, doi:10.1159/000016374.