Biochemistry: Organization of iron-sulfur clusters in respiratory complex I

P. Hinchliffe, L.A. Sazanov, Science 309 (2005) 771–774.

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Abstract
Complex I of respiratory chains plays a central role in bioenergetics and is implicated in many human neurodegenerative diseases. An understanding of its mechanism requires a knowledge of the organization of redox centers. The arrangement of iron-sulfur clusters in the hydrophilic domain of complex I from Thermus thermophilus has been determined with the use of x-ray crystallography. One binuclear and six tetranuclear clusters are arranged, maximally 14 angstroms apart, in an 84-angstrom-long electron transfer chain. The binuclear cluster N1a and the tetranuclear cluster N7 are not in this pathway. Cluster N1a may play a role in the prevention of oxidative damage. The structure provides a framework for the interpretation of the large amounts of data accumulated on complex I.
Publishing Year
Date Published
2005-07-29
Journal Title
Science
Acknowledgement
This work was funded by the Medical Research Council.
Volume
309
Issue
5735
Page
771 - 774
IST-REx-ID

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Hinchliffe P, Sazanov LA. Biochemistry: Organization of iron-sulfur clusters in respiratory complex I. Science. 2005;309(5735):771-774. doi:10.1126/science.1113988
Hinchliffe, P., & Sazanov, L. A. (2005). Biochemistry: Organization of iron-sulfur clusters in respiratory complex I. Science, 309(5735), 771–774. https://doi.org/10.1126/science.1113988
Hinchliffe, Philip, and Leonid A Sazanov. “Biochemistry: Organization of Iron-Sulfur Clusters in Respiratory Complex I.” Science 309, no. 5735 (2005): 771–74. https://doi.org/10.1126/science.1113988.
P. Hinchliffe and L. A. Sazanov, “Biochemistry: Organization of iron-sulfur clusters in respiratory complex I,” Science, vol. 309, no. 5735, pp. 771–774, 2005.
Hinchliffe P, Sazanov LA. 2005. Biochemistry: Organization of iron-sulfur clusters in respiratory complex I. Science. 309(5735), 771–774.
Hinchliffe, Philip, and Leonid A. Sazanov. “Biochemistry: Organization of Iron-Sulfur Clusters in Respiratory Complex I.” Science, vol. 309, no. 5735, American Association for the Advancement of Science, 2005, pp. 771–74, doi:10.1126/science.1113988.

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