Biomimetic membrane systems to study cellular organization

M. Loose, P. Schwille, Journal of Structural Biology 168 (2009) 143–151.

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Abstract
During many cellular processes such as cell division, polarization and motility, the plasma membrane does not only represent a passive physical barrier, but also provides a highly dynamic platform for the interplay between lipids, membrane binding proteins and cytoskeletal elements. Even though many regulators of these interactions are known, their mutual interdependence appears to be highly complex and difficult to study in a living cell. Over the past few years, in vitro studies on membrane-cytoskeleton interactions using biomimetic membranes turned out to be extremely helpful to get better mechanistic insight into the dynamics of these processes. In this review, we discuss some of the recent developments using in vitro assays to dissect the role of the players involved: lipids in the membrane, proteins binding to membranes and proteins binding to membrane proteins. We also summarize advantages and disadvantages of supported lipid bilayers as model membrane.
Publishing Year
Date Published
2009-10-01
Journal Title
Journal of Structural Biology
Volume
168
Issue
1
Page
143 - 151
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Loose M, Schwille P. Biomimetic membrane systems to study cellular organization. Journal of Structural Biology. 2009;168(1):143-151. doi:10.1016/j.jsb.2009.03.016
Loose, M., & Schwille, P. (2009). Biomimetic membrane systems to study cellular organization. Journal of Structural Biology, 168(1), 143–151. https://doi.org/10.1016/j.jsb.2009.03.016
Loose, Martin, and Petra Schwille. “Biomimetic Membrane Systems to Study Cellular Organization.” Journal of Structural Biology 168, no. 1 (2009): 143–51. https://doi.org/10.1016/j.jsb.2009.03.016.
M. Loose and P. Schwille, “Biomimetic membrane systems to study cellular organization,” Journal of Structural Biology, vol. 168, no. 1, pp. 143–151, 2009.
Loose M, Schwille P. 2009. Biomimetic membrane systems to study cellular organization. Journal of Structural Biology. 168(1), 143–151.
Loose, Martin, and Petra Schwille. “Biomimetic Membrane Systems to Study Cellular Organization.” Journal of Structural Biology, vol. 168, no. 1, Academic Press, 2009, pp. 143–51, doi:10.1016/j.jsb.2009.03.016.

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