A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila

B. Vicoso, P. Haddrill, B. Charlesworth, Genetical Research 90 (2008) 421–431.

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Abstract
Population genetics models show that, under certain conditions, the X chromosome is expected to be under more efficient selection than the autosomes. This could lead to 'faster-X evolution', if a large proportion of mutations are fixed by positive selection, as suggested by recent studies in Drosophila. We used a multispecies approach to test this: Muller's element D, an autosomal arm, is fused to the ancestral X chromosome in Drosophila pseudoobscura and its sister species, Drosophila affinis. We tested whether the same set of genes had higher rates of non-synonymous evolution when they were X-linked (in the D. pseudoobscura/D. affinis comparison) than when they were autosomal (in Drosophila melanogaster/Drosophila yakuba). Although not significant, our results suggest this may be the case, but only for genes under particularly strong positive selection/weak purifying selection. They also suggest that genes that have become X-linked have higher levels of codon bias and slower synonymous site evolution, consistent with more effective selection on codon usage at X-linked sites.
Publishing Year
Date Published
2008-10-01
Journal Title
Genetical Research
Acknowledgement
B.V. was supported by the Portuguese Foundation for Science and Technology, P.R.H. is supported by the Natural Environmental Research Council (UK) and B.C. was supported by the Royal Society (UK)
Volume
90
Issue
5
Page
421 - 431
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Vicoso B, Haddrill P, Charlesworth B. A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. Genetical Research. 2008;90(5):421-431. doi:10.1017/S0016672308009804
Vicoso, B., Haddrill, P., & Charlesworth, B. (2008). A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. Genetical Research, 90(5), 421–431. https://doi.org/10.1017/S0016672308009804
Vicoso, Beatriz, Penelope Haddrill, and Brian Charlesworth. “A Multispecies Approach for Comparing Sequence Evolution of X-Linked and Autosomal Sites in Drosophila.” Genetical Research 90, no. 5 (2008): 421–31. https://doi.org/10.1017/S0016672308009804.
B. Vicoso, P. Haddrill, and B. Charlesworth, “A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila,” Genetical Research, vol. 90, no. 5, pp. 421–431, 2008.
Vicoso B, Haddrill P, Charlesworth B. 2008. A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. Genetical Research. 90(5), 421–431.
Vicoso, Beatriz, et al. “A Multispecies Approach for Comparing Sequence Evolution of X-Linked and Autosomal Sites in Drosophila.” Genetical Research, vol. 90, no. 5, Cambridge University Press, 2008, pp. 421–31, doi:10.1017/S0016672308009804.

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