Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer

K. Matsuda, E. Miura, T. Miyazaki, W. Kakegawa, K. Emi, S. Narumi, Y. Fukazawa, A. Ito Lshida, T. Kondo, R. Shigemoto, M. Watanabe, M. Yuzaki, Science 328 (2010) 363–368.

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Abstract
Cbln1, secreted from cerebellar granule cells, and the orphan glutamate receptor 52 (GluD2), expressed by Purkinje cells, are essential for synapse integrity between these neurons in adult mice. Nevertheless, no endogenous binding partners for these molecules have been identified. We found that Cblnl binds directly to the N-terminal domain of GluD2. GluD2 expression by postsynaptic cells, combined with exogenously applied Cbln1, was necessary and sufficient to induce new synapses in vitro and in the adult cerebellum in vivo. Further, beads coated with recombinant Cbln1 directly induced presynaptic differentiation and indirectly caused clustering of postsynaptic molecules via GluD2. These results indicate that the Cbln1-GluD2 complex is a unique synapse organizer that acts bidirectionally on both pre- and postsynaptic components.
Publishing Year
Date Published
2010-04-16
Journal Title
Science
Volume
328
Issue
5976
Page
363 - 368
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Matsuda K, Miura E, Miyazaki T, et al. Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer. Science. 2010;328(5976):363-368. doi:10.1126/science.1185152
Matsuda, K., Miura, E., Miyazaki, T., Kakegawa, W., Emi, K., Narumi, S., … Yuzaki, M. (2010). Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer. Science, 328(5976), 363–368. https://doi.org/10.1126/science.1185152
Matsuda, Keiko, Eriko Miura, Taisuke Miyazaki, Wataru Kakegawa, Kyoichi Emi, Sakae Narumi, Yugo Fukazawa, et al. “Cbln1 Is a Ligand for an Orphan Glutamate Receptor Δ2, a Bidirectional Synapse Organizer.” Science 328, no. 5976 (2010): 363–68. https://doi.org/10.1126/science.1185152.
K. Matsuda et al., “Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer,” Science, vol. 328, no. 5976, pp. 363–368, 2010.
Matsuda K, Miura E, Miyazaki T, Kakegawa W, Emi K, Narumi S, Fukazawa Y, Ito Lshida A, Kondo T, Shigemoto R, Watanabe M, Yuzaki M. 2010. Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer. Science. 328(5976), 363–368.
Matsuda, Keiko, et al. “Cbln1 Is a Ligand for an Orphan Glutamate Receptor Δ2, a Bidirectional Synapse Organizer.” Science, vol. 328, no. 5976, American Association for the Advancement of Science, 2010, pp. 363–68, doi:10.1126/science.1185152.

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