Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression

Y. Fukazawa, R. Shigemoto, Current Opinion in Neurobiology 22 (2012) 446–452.

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Abstract
To gain insights into structure-function relationship of excitatory synapses, we revisit our quantitative analysis of synaptic AMPAR by highly sensitive freeze-fracture replica labeling in eight different connections. All of these connections showed linear correlation between synapse size and AMPAR number indicating a common intra-synapse-type relationship in CNS synapses. On the contrary, inter-synapse-type relationship is unexpected indicating no correlation between averages of synapse size and AMPAR number. Interestingly, connections with large average synapse size and low AMPAR density showed high variability of AMPAR number and mosaic distribution within the postsynaptic membrane. We propose an idea that these connections may quickly exhibit synaptic plasticity by modifying AMPAR density/number whereas those with high AMPAR density change their efficacy by modifying synapse size.
Publishing Year
Date Published
2012-06-01
Journal Title
Current Opinion in Neurobiology
Volume
22
Issue
3
Page
446 - 452
IST-REx-ID

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Fukazawa Y, Shigemoto R. Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression. Current Opinion in Neurobiology. 2012;22(3):446-452. doi:10.1016/j.conb.2012.01.006
Fukazawa, Y., & Shigemoto, R. (2012). Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression. Current Opinion in Neurobiology, 22(3), 446–452. https://doi.org/10.1016/j.conb.2012.01.006
Fukazawa, Yugo, and Ryuichi Shigemoto. “Intra-Synapse-Type and Inter-Synapse-Type Relationships between Synaptic Size and AMPAR Expression.” Current Opinion in Neurobiology 22, no. 3 (2012): 446–52. https://doi.org/10.1016/j.conb.2012.01.006.
Y. Fukazawa and R. Shigemoto, “Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression,” Current Opinion in Neurobiology, vol. 22, no. 3, pp. 446–452, 2012.
Fukazawa Y, Shigemoto R. 2012. Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression. Current Opinion in Neurobiology. 22(3), 446–452.
Fukazawa, Yugo, and Ryuichi Shigemoto. “Intra-Synapse-Type and Inter-Synapse-Type Relationships between Synaptic Size and AMPAR Expression.” Current Opinion in Neurobiology, vol. 22, no. 3, Elsevier, 2012, pp. 446–52, doi:10.1016/j.conb.2012.01.006.

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