Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells.

N. Burnashev, A. Khodorova, P.M. Jonas, P. Helm, W. Wisden, H. Monyer, P. Seeburg, B. Sakmann, Science 256 (1992) 1566–1570.

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Abstract
Glutamate-operated ion channels (GluR channels) of the L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-kainate subtype are found in both neurons and glial cells of the central nervous system. These channels are assembled from the GluR-A, -B, -C, and -D subunits; channels containing a GluR-B subunit show an outwardly rectifying current-voltage relation and low calcium permeability, whereas channels lacking the GluR-B subunit are characterized by a doubly rectifying current-voltage relation and high calcium permeability. Most cell types in the central nervous system coexpress several subunits, including GluR-B. However, Bergmann glia in rat cerebellum do not express GluR-B subunit genes. In a subset of cultured cerebellar glial cells, likely derived from Bergmann glial cells. GluR channels exhibit doubly rectifying current-voltage relations and high calcium permeability, whereas GluR channels of cerebellar neurons have low calcium permeability. Thus, differential expression of the GluR-B subunit gene in neurons and glia is one mechanism by which functional properties of native GluR channels are regulated.
Publishing Year
Date Published
1992-06-12
Journal Title
Science
Volume
256
Issue
5063
Page
1566 - 1570
IST-REx-ID

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Burnashev N, Khodorova A, Jonas PM, et al. Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells. Science. 1992;256(5063):1566-1570. doi:10.1126/science.1317970
Burnashev, N., Khodorova, A., Jonas, P. M., Helm, P., Wisden, W., Monyer, H., … Sakmann, B. (1992). Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells. Science, 256(5063), 1566–1570. https://doi.org/10.1126/science.1317970
Burnashev, Nail, Alla Khodorova, Peter M Jonas, P. Helm, William Wisden, Hannah Monyer, Peter Seeburg, and Bert Sakmann. “Calcium-Permeable AMPA-Kainate Receptors in Fusiform Cerebellar Glial Cells.” Science 256, no. 5063 (1992): 1566–70. https://doi.org/10.1126/science.1317970.
N. Burnashev et al., “Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells.,” Science, vol. 256, no. 5063, pp. 1566–1570, 1992.
Burnashev N, Khodorova A, Jonas PM, Helm P, Wisden W, Monyer H, Seeburg P, Sakmann B. 1992. Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells. Science. 256(5063), 1566–1570.
Burnashev, Nail, et al. “Calcium-Permeable AMPA-Kainate Receptors in Fusiform Cerebellar Glial Cells.” Science, vol. 256, no. 5063, American Association for the Advancement of Science, 1992, pp. 1566–70, doi:10.1126/science.1317970.

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