[{"language":[{}],"file":[{"creator":"dernst","date_updated":"2022-05-13T08:03:37Z","file_size":9010446,"date_created":"2022-05-13T08:03:37Z","file_name":"2021_eLife_Pulgar.pdf","access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_id":"11371","checksum":"a3f82b0499cc822ac1eab48a01f3f57e","success":1}],"publication_status":"published","publication_identifier":{"eissn":[]},"ec_funded":1,"volume":10,"oa_version":"Published Version","pmid":1,"abstract":[{"lang":"eng"}],"intvolume":" 10","month":"08","scopus_import":"1","ddc":[],"creator":{"login":"cchlebak","id":"8b945eb4-e2f2-11eb-945a-df72226e66a9"},"date_updated":"2023-08-14T06:53:33Z","department":[{"_id":"CaHe","tree":[{"_id":"ResearchGroups"},{"_id":"IST"}]}],"file_date_updated":"2022-05-13T08:03:37Z","_id":"9999","keyword":[],"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"original","type":"journal_article","publication":"eLife","dc":{"publisher":["eLife Sciences Publications"],"type":["info:eu-repo/semantics/article","doc-type:article","text","http://purl.org/coar/resource_type/c_6501"],"date":["2021"],"identifier":["https://research-explorer.ista.ac.at/record/9999","https://research-explorer.ista.ac.at/download/9999/11371"],"description":["The developmental strategies used by progenitor cells to endure a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here we uncovered a progenitor cell allocation mechanism that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the surface epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-term apical contacts that enable the epithelial layer to pull a subset of progenitors along their way towards the vegetal pole. The remaining delaminated progenitors follow apically-attached progenitors’ movement by a co-attraction mechanism, avoiding sequestration by the adjacent endoderm, ensuring their fate and collective allocation at the differentiation site. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development. Impact Statement: Incomplete delamination serves as a cellular platform for coordinated tissue movements during development, guiding newly formed progenitor cell groups to the differentiation site."],"relation":["info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.66483","info:eu-repo/semantics/altIdentifier/issn/2050-084X","info:eu-repo/semantics/altIdentifier/wos/000700428500001","info:eu-repo/semantics/altIdentifier/pmid/34448451","info:eu-repo/grantAgreement/EC/H2020/742573"],"source":["Pulgar E, Schwayer C, Guerrero N, et al. Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. eLife. 2021;10. doi:10.7554/eLife.66483"],"title":["Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism"],"subject":["cell delamination","apical constriction","dragging","mechanical forces","collective 18 locomotion","dorsal forerunner cells","zebrafish","ddc:570"],"language":["eng"],"rights":["https://creativecommons.org/licenses/by/4.0/","info:eu-repo/semantics/openAccess"],"creator":["Pulgar, Eduardo","Schwayer, Cornelia","Guerrero, Néstor","López, Loreto","Márquez, Susana","Härtel, Steffen","Soto, Rodrigo","Heisenberg, Carl Philipp","Concha, Miguel L."]},"day":"27","isi":1,"has_accepted_license":"1","date_created":"2021-09-12T22:01:23Z","date_published":"2021-08-27T00:00:00Z","uri_base":"https://research-explorer.ista.ac.at","oa":1,"quality_controlled":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","dini_type":"doc-type:article","citation":{"short":"E. Pulgar, C. Schwayer, N. Guerrero, L. López, S. Márquez, S. Härtel, R. Soto, C.P. Heisenberg, M.L. Concha, ELife 10 (2021).","ieee":"E. Pulgar et al., “Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism,” eLife, vol. 10. eLife Sciences Publications, 2021.","apa":"Pulgar, E., Schwayer, C., Guerrero, N., López, L., Márquez, S., Härtel, S., … Concha, M. L. (2021). Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.66483","mla":"Pulgar, Eduardo, et al. “Apical Contacts Stemming from Incomplete Delamination Guide Progenitor Cell Allocation through a Dragging Mechanism.” ELife, vol. 10, e66483, eLife Sciences Publications, 2021, doi:10.7554/eLife.66483.","ista":"Pulgar E, Schwayer C, Guerrero N, López L, Márquez S, Härtel S, Soto R, Heisenberg CP, Concha ML. 2021. Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. eLife. 10, e66483.","chicago":"Pulgar, Eduardo, Cornelia Schwayer, Néstor Guerrero, Loreto López, Susana Márquez, Steffen Härtel, Rodrigo Soto, Carl Philipp Heisenberg, and Miguel L. Concha. “Apical Contacts Stemming from Incomplete Delamination Guide Progenitor Cell Allocation through a Dragging Mechanism.” ELife. eLife Sciences Publications, 2021. https://doi.org/10.7554/eLife.66483."},"external_id":{"pmid":[],"isi":[]},"article_processing_charge":"Yes","author":[{"last_name":"Pulgar","first_name":"Eduardo"},{"id":"3436488C-F248-11E8-B48F-1D18A9856A87","first_name":"Cornelia","orcid":"0000-0001-5130-2226","last_name":"Schwayer"},{"last_name":"Guerrero","first_name":"Néstor"},{"first_name":"Loreto","last_name":"López"},{"first_name":"Susana","last_name":"Márquez"},{"first_name":"Steffen","last_name":"Härtel"},{"last_name":"Soto","first_name":"Rodrigo"},{"first_name":"Carl Philipp","last_name":"Heisenberg"},{"last_name":"Concha","first_name":"Miguel L."}],"article_number":"e66483","project":[{"_id":"260F1432-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation"}]}]