{"month":"02","date_updated":"2023-09-22T09:41:20Z","date_created":"2021-08-10T08:12:52Z","department":[{"_id":"BeVi"}],"_id":"9861","title":"Data from: X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster","main_file_link":[{"url":"https://doi.org/10.5061/dryad.02f6r","open_access":"1"}],"date_published":"2017-02-14T00:00:00Z","author":[{"last_name":"Argyridou","full_name":"Argyridou, Eliza","first_name":"Eliza"},{"first_name":"Ann K","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","last_name":"Huylmans","full_name":"Huylmans, Ann K","orcid":"0000-0001-8871-4961"},{"first_name":"Annabella","full_name":"Königer, Annabella","last_name":"Königer"},{"first_name":"John","last_name":"Parsch","full_name":"Parsch, John"}],"status":"public","type":"research_data_reference","year":"2017","day":"14","citation":{"apa":"Argyridou, E., Huylmans, A. K., Königer, A., &#38; Parsch, J. (2017). Data from: X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster. Dryad. <a href=\"https://doi.org/10.5061/dryad.02f6r\">https://doi.org/10.5061/dryad.02f6r</a>","short":"E. Argyridou, A.K. Huylmans, A. Königer, J. Parsch, (2017).","mla":"Argyridou, Eliza, et al. <i>Data from: X-Linkage Is Not a General Inhibitor of Tissue-Specific Gene Expression in Drosophila Melanogaster</i>. Dryad, 2017, doi:<a href=\"https://doi.org/10.5061/dryad.02f6r\">10.5061/dryad.02f6r</a>.","ista":"Argyridou E, Huylmans AK, Königer A, Parsch J. 2017. Data from: X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster, Dryad, <a href=\"https://doi.org/10.5061/dryad.02f6r\">10.5061/dryad.02f6r</a>.","ama":"Argyridou E, Huylmans AK, Königer A, Parsch J. Data from: X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster. 2017. doi:<a href=\"https://doi.org/10.5061/dryad.02f6r\">10.5061/dryad.02f6r</a>","ieee":"E. Argyridou, A. K. Huylmans, A. Königer, and J. Parsch, “Data from: X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster.” Dryad, 2017.","chicago":"Argyridou, Eliza, Ann K Huylmans, Annabella Königer, and John Parsch. “Data from: X-Linkage Is Not a General Inhibitor of Tissue-Specific Gene Expression in Drosophila Melanogaster.” Dryad, 2017. <a href=\"https://doi.org/10.5061/dryad.02f6r\">https://doi.org/10.5061/dryad.02f6r</a>."},"oa":1,"oa_version":"Published Version","doi":"10.5061/dryad.02f6r","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","article_processing_charge":"No","related_material":{"record":[{"relation":"used_in_publication","id":"1019","status":"public"}]},"publisher":"Dryad","abstract":[{"text":"As a consequence of its difference in copy number between males and females, the X chromosome is subject to unique evolutionary forces and gene regulatory mechanisms. Previous studies of Drosophila melanogaster have shown that the expression of X-linked, testis-specific reporter genes is suppressed in the male germline. However, it is not known whether this phenomenon is restricted to testis-expressed genes or if it is a more general property of genes with tissue-specific expression, which are also underrepresented on the X chromosome. To test this, we compared the expression of three tissue-specific reporter genes (ovary, accessory gland and Malpighian tubule) inserted at various autosomal and X-chromosomal locations. In contrast to testis-specific reporter genes, we found no reduction of X-linked expression in any of the other tissues. In accessory gland and Malpighian tubule, we detected higher expression of the X-linked reporter genes, which suggests that they are at least partially dosage compensated. We found no difference in the tissue-specificity of X-linked and autosomal reporter genes. These findings indicate that, in general, the X chromosome is not a detrimental environment for tissue-specific gene expression and that the suppression of X-linked expression is limited to the male germline.","lang":"eng"}]}