---
_id: '9806'
abstract:
- lang: eng
text: 1. Hosts can alter their strategy towards pathogens during their lifetime,
i.e., they can show phenotypic plasticity in immunity or life history. Immune
priming is one such example, where a previous encounter with a pathogen confers
enhanced protection upon secondary challenge, resulting in reduced pathogen load
(i.e. resistance) and improved host survival. However, an initial encounter might
also enhance tolerance, particularly to less virulent opportunistic pathogens
that establish persistent infections. In this scenario, individuals are better
able to reduce the negative fitness consequences that result from a high pathogen
load. Finally, previous exposure may also lead to life history adjustments, such
as terminal investment into reproduction. 2. Using different Drosophila melanogaster
host genotypes and two bacterial pathogens, Lactococcus lactis and Pseudomonas
entomophila, we tested if previous exposure results in resistance or tolerance
and whether it modifies immune gene expression during an acute-phase infection
(one day post-challenge). We then asked if previous pathogen exposure affects
chronic-phase pathogen persistence and longer-term survival (28 days post-challenge).
3. We predicted that previous exposure would increase host resistance to an early
stage bacterial infection while it might come at a cost to host fecundity tolerance.
We reasoned that resistance would be due in part to stronger immune gene expression
after challenge. We expected that previous exposure would improve long-term survival,
that it would reduce infection persistence, and we expected to find genetic variation
in these responses. 4. We found that previous exposure to P. entomophila weakened
host resistance to a second infection independent of genotype and had no effect
on immune gene expression. Fecundity tolerance showed genotypic variation but
was not influenced by previous exposure. However, L. lactis persisted as a chronic
infection, whereas survivors cleared the more pathogenic P. entomophila infection.
5. To our knowledge, this is the first study that addresses host tolerance to
bacteria in relation to previous exposure, taking a multi-faceted approach to
address the topic. Our results suggest that previous exposure comes with transient
costs to resistance during the early stage of infection in this host-pathogen
system and that infection persistence may be bacterium-specific.
article_processing_charge: No
author:
- first_name: Megan
full_name: Kutzer, Megan
id: 29D0B332-F248-11E8-B48F-1D18A9856A87
last_name: Kutzer
orcid: 0000-0002-8696-6978
- first_name: Joachim
full_name: Kurtz, Joachim
last_name: Kurtz
- first_name: Sophie A.O.
full_name: Armitage, Sophie A.O.
last_name: Armitage
citation:
ama: 'Kutzer M, Kurtz J, Armitage SAO. Data from: A multi-faceted approach testing
the effects of previous bacterial exposure on resistance and tolerance. 2019.
doi:10.5061/dryad.9kj41f0'
apa: 'Kutzer, M., Kurtz, J., & Armitage, S. A. O. (2019). Data from: A multi-faceted
approach testing the effects of previous bacterial exposure on resistance and
tolerance. Dryad. https://doi.org/10.5061/dryad.9kj41f0'
chicago: 'Kutzer, Megan, Joachim Kurtz, and Sophie A.O. Armitage. “Data from: A
Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance
and Tolerance.” Dryad, 2019. https://doi.org/10.5061/dryad.9kj41f0.'
ieee: 'M. Kutzer, J. Kurtz, and S. A. O. Armitage, “Data from: A multi-faceted approach
testing the effects of previous bacterial exposure on resistance and tolerance.”
Dryad, 2019.'
ista: 'Kutzer M, Kurtz J, Armitage SAO. 2019. Data from: A multi-faceted approach
testing the effects of previous bacterial exposure on resistance and tolerance,
Dryad, 10.5061/dryad.9kj41f0.'
mla: 'Kutzer, Megan, et al. Data from: A Multi-Faceted Approach Testing the Effects
of Previous Bacterial Exposure on Resistance and Tolerance. Dryad, 2019, doi:10.5061/dryad.9kj41f0.'
short: M. Kutzer, J. Kurtz, S.A.O. Armitage, (2019).
date_created: 2021-08-06T12:06:40Z
date_published: 2019-02-05T00:00:00Z
date_updated: 2023-08-25T08:04:52Z
day: '05'
department:
- _id: SyCr
doi: 10.5061/dryad.9kj41f0
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.9kj41f0
month: '02'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '6105'
relation: used_in_publication
status: public
status: public
title: 'Data from: A multi-faceted approach testing the effects of previous bacterial
exposure on resistance and tolerance'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...