{"type":"journal_article","publisher":"Nature Publishing Group","publication_identifier":{"issn":["20411723"]},"language":[{"iso":"eng"}],"external_id":{"isi":["000407198800005"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","month":"08","volume":8,"oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"file":[{"date_created":"2018-12-12T10:14:14Z","date_updated":"2020-07-14T12:48:16Z","access_level":"open_access","checksum":"29a1b5db458048d3bd5c67e0e2a56818","file_size":998157,"file_id":"5064","content_type":"application/pdf","file_name":"IST-2017-864-v1+1_s41467-017-00238-8.pdf","creator":"system","relation":"main_file"},{"checksum":"7b78401e52a576cf3e6bbf8d0abadc17","date_updated":"2020-07-14T12:48:16Z","date_created":"2018-12-12T10:14:15Z","access_level":"open_access","file_id":"5065","relation":"main_file","file_name":"IST-2017-864-v1+2_41467_2017_238_MOESM1_ESM.pdf","creator":"system","content_type":"application/pdf","file_size":9715993}],"abstract":[{"text":"Gene expression is controlled by networks of regulatory proteins that interact specifically with external signals and DNA regulatory sequences. These interactions force the network components to co-evolve so as to continually maintain function. Yet, existing models of evolution mostly focus on isolated genetic elements. In contrast, we study the essential process by which regulatory networks grow: the duplication and subsequent specialization of network components. We synthesize a biophysical model of molecular interactions with the evolutionary framework to find the conditions and pathways by which new regulatory functions emerge. We show that specialization of new network components is usually slow, but can be drastically accelerated in the presence of regulatory crosstalk and mutations that promote promiscuous interactions between network components.","lang":"eng"}],"doi":"10.1038/s41467-017-00238-8","day":"09","_id":"955","author":[{"first_name":"Tamar","last_name":"Friedlander","id":"36A5845C-F248-11E8-B48F-1D18A9856A87","full_name":"Friedlander, Tamar"},{"first_name":"Roshan","full_name":"Prizak, Roshan","last_name":"Prizak","id":"4456104E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Nicholas H","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","orcid":"0000-0002-8548-5240"},{"orcid":"0000-0002-6699-1455","first_name":"Gasper","full_name":"Tkacik, Gasper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","last_name":"Tkacik"}],"article_processing_charge":"Yes (in subscription journal)","department":[{"_id":"GaTk"},{"_id":"NiBa"}],"title":"Evolution of new regulatory functions on biophysically realistic fitness landscapes","publication":"Nature Communications","publist_id":"6459","citation":{"ista":"Friedlander T, Prizak R, Barton NH, Tkačik G. 2017. Evolution of new regulatory functions on biophysically realistic fitness landscapes. Nature Communications. 8(1), 216.","mla":"Friedlander, Tamar, et al. “Evolution of New Regulatory Functions on Biophysically Realistic Fitness Landscapes.” <i>Nature Communications</i>, vol. 8, no. 1, 216, Nature Publishing Group, 2017, doi:<a href=\"https://doi.org/10.1038/s41467-017-00238-8\">10.1038/s41467-017-00238-8</a>.","apa":"Friedlander, T., Prizak, R., Barton, N. H., &#38; Tkačik, G. (2017). Evolution of new regulatory functions on biophysically realistic fitness landscapes. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41467-017-00238-8\">https://doi.org/10.1038/s41467-017-00238-8</a>","short":"T. Friedlander, R. Prizak, N.H. Barton, G. Tkačik, Nature Communications 8 (2017).","ieee":"T. Friedlander, R. Prizak, N. H. Barton, and G. Tkačik, “Evolution of new regulatory functions on biophysically realistic fitness landscapes,” <i>Nature Communications</i>, vol. 8, no. 1. Nature Publishing Group, 2017.","chicago":"Friedlander, Tamar, Roshan Prizak, Nicholas H Barton, and Gašper Tkačik. “Evolution of New Regulatory Functions on Biophysically Realistic Fitness Landscapes.” <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/s41467-017-00238-8\">https://doi.org/10.1038/s41467-017-00238-8</a>.","ama":"Friedlander T, Prizak R, Barton NH, Tkačik G. Evolution of new regulatory functions on biophysically realistic fitness landscapes. <i>Nature Communications</i>. 2017;8(1). doi:<a href=\"https://doi.org/10.1038/s41467-017-00238-8\">10.1038/s41467-017-00238-8</a>"},"pubrep_id":"864","related_material":{"record":[{"status":"public","id":"6071","relation":"dissertation_contains"}]},"status":"public","ddc":["539","576"],"has_accepted_license":"1","ec_funded":1,"quality_controlled":"1","article_number":"216","date_updated":"2023-09-22T10:00:49Z","oa_version":"Published Version","publication_status":"published","date_created":"2018-12-11T11:49:23Z","year":"2017","date_published":"2017-08-09T00:00:00Z","file_date_updated":"2020-07-14T12:48:16Z","isi":1,"project":[{"call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"},{"grant_number":"250152","name":"Limits to selection in biology and in evolutionary computation","_id":"25B07788-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"},{"_id":"254E9036-B435-11E9-9278-68D0E5697425","name":"Biophysics of information processing in gene regulation","call_identifier":"FWF","grant_number":"P28844-B27"}],"scopus_import":"1","intvolume":"         8","issue":"1"}