Evolution of new regulatory functions on biophysically realistic fitness landscapes

T. Friedlander, R. Prizak, N.H. Barton, G. Tkacik, Nature Communications 8 (2017) 216.

Download
OA 998.16 KB
OA IST-2017-864-v1+2_41467_2017_238_MOESM1_ESM.pdf 9.72 MB

Journal Article | Published | English
Abstract
Gene expression is controlled by networks of regulatory proteins that interact specifically with external signals and DNA regulatory sequences. These interactions force the network components to co-evolve so as to continually maintain function. Yet, existing models of evolution mostly focus on isolated genetic elements. In contrast, we study the essential process by which regulatory networks grow: the duplication and subsequent specialization of network components. We synthesize a biophysical model of molecular interactions with the evolutionary framework to find the conditions and pathways by which new regulatory functions emerge. We show that specialization of new network components is usually slow, but can be drastically accelerated in the presence of regulatory crosstalk and mutations that promote promiscuous interactions between network components.
Publishing Year
Date Published
2017-08-09
Journal Title
Nature Communications
Volume
8
Issue
1
Article Number
216
ISSN
IST-REx-ID

Cite this

Friedlander T, Prizak R, Barton NH, Tkacik G. Evolution of new regulatory functions on biophysically realistic fitness landscapes. Nature Communications. 2017;8(1):216. doi:10.1038/s41467-017-00238-8
Friedlander, T., Prizak, R., Barton, N. H., & Tkacik, G. (2017). Evolution of new regulatory functions on biophysically realistic fitness landscapes. Nature Communications, 8(1), 216. https://doi.org/10.1038/s41467-017-00238-8
Friedlander, Tamar, Roshan Prizak, Nicholas H Barton, and Gasper Tkacik. “Evolution of New Regulatory Functions on Biophysically Realistic Fitness Landscapes.” Nature Communications 8, no. 1 (2017): 216. https://doi.org/10.1038/s41467-017-00238-8.
T. Friedlander, R. Prizak, N. H. Barton, and G. Tkacik, “Evolution of new regulatory functions on biophysically realistic fitness landscapes,” Nature Communications, vol. 8, no. 1, p. 216, 2017.
Friedlander T, Prizak R, Barton NH, Tkacik G. 2017. Evolution of new regulatory functions on biophysically realistic fitness landscapes. Nature Communications. 8(1), 216.
Friedlander, Tamar, et al. “Evolution of New Regulatory Functions on Biophysically Realistic Fitness Landscapes.” Nature Communications, vol. 8, no. 1, Nature Publishing Group, 2017, p. 216, doi:10.1038/s41467-017-00238-8.
All files available under the following license(s):
Creative Commons License:
CC-BYCreative Commons Attribution 4.0 International Public License (CC-BY 4.0)
Main File(s)
Access Level
OA Open Access
Last Uploaded
2018-12-12T10:14:14Z
Access Level
OA Open Access
Last Uploaded
2018-12-12T10:14:15Z


Material in IST:
Dissertation containing IST record

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar