{"abstract":[{"lang":"eng","text":"Cytosine methylation is the most common covalent modification of DNA in eukaryotes. DNA methylation has an important role in many aspects of biology, including development and disease. Methylation can be detected using bisulfite conversion, methylation-sensitive restriction enzymes, methyl-binding proteins and anti-methylcytosine antibodies. Combining these techniques with DNA microarrays and high-throughput sequencing has made the mapping of DNA methylation feasible on a genome-wide scale. Here we discuss recent developments and future directions for identifying and mapping methylation, in an effort to help colleagues to identify the approaches that best serve their research interests."}],"citation":{"ieee":"D. Zilberman and S. Henikoff, “Genome-wide analysis of DNA methylation patterns,” <i>Development</i>, vol. 134, no. 22. The Company of Biologists, pp. 3959–3965, 2007.","ista":"Zilberman D, Henikoff S. 2007. Genome-wide analysis of DNA methylation patterns. Development. 134(22), 3959–3965.","chicago":"Zilberman, Daniel, and Steven Henikoff. “Genome-Wide Analysis of DNA Methylation Patterns.” <i>Development</i>. The Company of Biologists, 2007. <a href=\"https://doi.org/10.1242/dev.001131\">https://doi.org/10.1242/dev.001131</a>.","mla":"Zilberman, Daniel, and Steven Henikoff. “Genome-Wide Analysis of DNA Methylation Patterns.” <i>Development</i>, vol. 134, no. 22, The Company of Biologists, 2007, pp. 3959–65, doi:<a href=\"https://doi.org/10.1242/dev.001131\">10.1242/dev.001131</a>.","short":"D. Zilberman, S. Henikoff, Development 134 (2007) 3959–3965.","ama":"Zilberman D, Henikoff S. Genome-wide analysis of DNA methylation patterns. <i>Development</i>. 2007;134(22):3959-3965. doi:<a href=\"https://doi.org/10.1242/dev.001131\">10.1242/dev.001131</a>","apa":"Zilberman, D., &#38; Henikoff, S. (2007). Genome-wide analysis of DNA methylation patterns. <i>Development</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/dev.001131\">https://doi.org/10.1242/dev.001131</a>"},"language":[{"iso":"eng"}],"department":[{"_id":"DaZi"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","title":"Genome-wide analysis of DNA methylation patterns","author":[{"first_name":"Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","full_name":"Zilberman, Daniel","orcid":"0000-0002-0123-8649","last_name":"Zilberman"},{"first_name":"Steven","last_name":"Henikoff","full_name":"Henikoff, Steven"}],"publication_status":"published","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1242/dev.001131"}],"oa":1,"article_type":"review","issue":"22","external_id":{"pmid":["17928417"]},"volume":134,"publication":"Development","pmid":1,"status":"public","date_created":"2021-06-08T06:29:50Z","doi":"10.1242/dev.001131","article_processing_charge":"No","date_published":"2007-11-15T00:00:00Z","extern":"1","intvolume":"       134","month":"11","day":"15","type":"journal_article","scopus_import":"1","oa_version":"Published Version","date_updated":"2021-12-14T08:57:58Z","quality_controlled":"1","page":"3959-3965","year":"2007","publication_identifier":{"issn":["0950-1991"],"eissn":["1477-9129"]},"publisher":"The Company of Biologists","_id":"9524"}