Genome-wide analysis of DNA methylation patterns

ZILBERMAN D, Henikoff S. 2007. Genome-wide analysis of DNA methylation patterns. Development. 134(22), 3959–3965.


Journal Article | Published | English

Scopus indexed
Author
ZILBERMAN, DanielIST Austria; Henikoff, Steven
Abstract
Cytosine methylation is the most common covalent modification of DNA in eukaryotes. DNA methylation has an important role in many aspects of biology, including development and disease. Methylation can be detected using bisulfite conversion, methylation-sensitive restriction enzymes, methyl-binding proteins and anti-methylcytosine antibodies. Combining these techniques with DNA microarrays and high-throughput sequencing has made the mapping of DNA methylation feasible on a genome-wide scale. Here we discuss recent developments and future directions for identifying and mapping methylation, in an effort to help colleagues to identify the approaches that best serve their research interests.
Publishing Year
Date Published
2007-11-15
Journal Title
Development
Volume
134
Issue
22
Page
3959-3965
ISSN
eISSN
IST-REx-ID

Cite this

ZILBERMAN D, Henikoff S. Genome-wide analysis of DNA methylation patterns. Development. 2007;134(22):3959-3965. doi:10.1242/dev.001131
ZILBERMAN, D., & Henikoff, S. (2007). Genome-wide analysis of DNA methylation patterns. Development. The Company of Biologists. https://doi.org/10.1242/dev.001131
ZILBERMAN, Daniel, and Steven Henikoff. “Genome-Wide Analysis of DNA Methylation Patterns.” Development. The Company of Biologists, 2007. https://doi.org/10.1242/dev.001131.
D. ZILBERMAN and S. Henikoff, “Genome-wide analysis of DNA methylation patterns,” Development, vol. 134, no. 22. The Company of Biologists, pp. 3959–3965, 2007.
ZILBERMAN D, Henikoff S. 2007. Genome-wide analysis of DNA methylation patterns. Development. 134(22), 3959–3965.
ZILBERMAN, Daniel, and Steven Henikoff. “Genome-Wide Analysis of DNA Methylation Patterns.” Development, vol. 134, no. 22, The Company of Biologists, 2007, pp. 3959–65, doi:10.1242/dev.001131.
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