--- _id: '9452' abstract: - lang: eng text: Eukaryotic cytosine methylation represses transcription but also occurs in the bodies of active genes, and the extent of methylation biology conservation is unclear. We quantified DNA methylation in 17 eukaryotic genomes and found that gene body methylation is conserved between plants and animals, whereas selective methylation of transposons is not. We show that methylation of plant transposons in the CHG context extends to green algae and that exclusion of histone H2A.Z from methylated DNA is conserved between plants and animals, and we present evidence for RNA-directed DNA methylation of fungal genes. Our data demonstrate that extant DNA methylation systems are mosaics of conserved and derived features, and indicate that gene body methylation is an ancient property of eukaryotic genomes. article_processing_charge: No article_type: original author: - first_name: 'Assaf ' full_name: 'Zemach, Assaf ' last_name: Zemach - first_name: Ivy E. full_name: McDaniel, Ivy E. last_name: McDaniel - first_name: Pedro full_name: Silva, Pedro last_name: Silva - first_name: Daniel full_name: Zilberman, Daniel id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1 last_name: Zilberman orcid: 0000-0002-0123-8649 citation: ama: Zemach A, McDaniel IE, Silva P, Zilberman D. Genome-wide evolutionary analysis of eukaryotic DNA methylation. Science. 2010;328(5980):916-919. doi:10.1126/science.1186366 apa: Zemach, A., McDaniel, I. E., Silva, P., & Zilberman, D. (2010). Genome-wide evolutionary analysis of eukaryotic DNA methylation. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1186366 chicago: Zemach, Assaf , Ivy E. McDaniel, Pedro Silva, and Daniel Zilberman. “Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation.” Science. American Association for the Advancement of Science, 2010. https://doi.org/10.1126/science.1186366. ieee: A. Zemach, I. E. McDaniel, P. Silva, and D. Zilberman, “Genome-wide evolutionary analysis of eukaryotic DNA methylation,” Science, vol. 328, no. 5980. American Association for the Advancement of Science, pp. 916–919, 2010. ista: Zemach A, McDaniel IE, Silva P, Zilberman D. 2010. Genome-wide evolutionary analysis of eukaryotic DNA methylation. Science. 328(5980), 916–919. mla: Zemach, Assaf, et al. “Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation.” Science, vol. 328, no. 5980, American Association for the Advancement of Science, 2010, pp. 916–19, doi:10.1126/science.1186366. short: A. Zemach, I.E. McDaniel, P. Silva, D. Zilberman, Science 328 (2010) 916–919. date_created: 2021-06-04T08:26:08Z date_published: 2010-05-14T00:00:00Z date_updated: 2021-12-14T08:35:37Z day: '14' department: - _id: DaZi doi: 10.1126/science.1186366 extern: '1' external_id: pmid: - '20395474 ' intvolume: ' 328' issue: '5980' keyword: - Multidisciplinary language: - iso: eng month: '05' oa_version: None page: 916-919 pmid: 1 publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' scopus_import: '1' status: public title: Genome-wide evolutionary analysis of eukaryotic DNA methylation type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 328 year: '2010' ...