Interplay of migratory and division forces as a generic mechanism for stem cell patterns

Hannezo EB, Coucke A, Joanny J. 2016. Interplay of migratory and division forces as a generic mechanism for stem cell patterns. Physical Review E Statistical Nonlinear and Soft Matter Physics. 93(2).

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Journal Article | Published | English
Author
Hannezo, Edouard IST Austria ; Coucke, Alice; Joanny, Jean
Abstract
In many adult tissues, stem cells and differentiated cells are not homogeneously distributed: stem cells are arranged in periodic "niches," and differentiated cells are constantly produced and migrate out of these niches. In this article, we provide a general theoretical framework to study mixtures of dividing and actively migrating particles, which we apply to biological tissues. We show in particular that the interplay between the stresses arising from active cell migration and stem cell division give rise to robust stem cell patterns. The instability of the tissue leads to spatial patterns which are either steady or oscillating in time. The wavelength of the instability has an order of magnitude consistent with the biological observations. We also discuss the implications of these results for future in vitro and in vivo experiments.
Publishing Year
Date Published
2016-02-28
Journal Title
Physical Review E Statistical Nonlinear and Soft Matter Physics
Acknowledgement
The authors thank Jacques Prost and Pierre Recho for helpful discussions, as well as the Labex CelTisPhyBio and all its members. E.H. acknowledges for funding a Young Researcher Prize from the Bettencourt-Schueller Fondation, and a Junior Research Fellowship from Trinity College, Cambridge.
Volume
93
Issue
2
IST-REx-ID
931

Cite this

Hannezo EB, Coucke A, Joanny J. Interplay of migratory and division forces as a generic mechanism for stem cell patterns. Physical Review E Statistical Nonlinear and Soft Matter Physics. 2016;93(2). doi:10.1103/PhysRevE.93.022405
Hannezo, E. B., Coucke, A., & Joanny, J. (2016). Interplay of migratory and division forces as a generic mechanism for stem cell patterns. Physical Review E Statistical Nonlinear and Soft Matter Physics. American Institute of Physics. https://doi.org/10.1103/PhysRevE.93.022405
Hannezo, Edouard B, Alice Coucke, and Jean Joanny. “Interplay of Migratory and Division Forces as a Generic Mechanism for Stem Cell Patterns.” Physical Review E Statistical Nonlinear and Soft Matter Physics. American Institute of Physics, 2016. https://doi.org/10.1103/PhysRevE.93.022405.
E. B. Hannezo, A. Coucke, and J. Joanny, “Interplay of migratory and division forces as a generic mechanism for stem cell patterns,” Physical Review E Statistical Nonlinear and Soft Matter Physics, vol. 93, no. 2. American Institute of Physics, 2016.
Hannezo EB, Coucke A, Joanny J. 2016. Interplay of migratory and division forces as a generic mechanism for stem cell patterns. Physical Review E Statistical Nonlinear and Soft Matter Physics. 93(2).
Hannezo, Edouard B., et al. “Interplay of Migratory and Division Forces as a Generic Mechanism for Stem Cell Patterns.” Physical Review E Statistical Nonlinear and Soft Matter Physics, vol. 93, no. 2, American Institute of Physics, 2016, doi:10.1103/PhysRevE.93.022405.

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