Engaging the front wheels to drive through fibrous terrain - Gärtner, Florian R; Sixt, Michael K (Developmental Cell, 2021)
In this issue of Developmental Cell, Doyle and colleagues identify periodic anterior contraction as a characteristic feature of fibroblasts and mesenchymal cancer cells embedded in 3D collagen gels. This contractile mechanism generates a matrix prestrain required for crawling in fibrous 3D environments.
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Keywords: article