---
_id: '899'
abstract:
- lang: eng
text: Understanding fitness landscapes, a conceptual depiction of the genotype-to-phenotype
relationship, is crucial to many areas of biology. Two aspects of fitness landscapes
are the focus of contemporary studies of molecular evolution. First, the local
shape of the fitness landscape defined by the contribution of individual alleles
to fitness that is independent of all genetic interactions. Second, the global,
multidimensional fitness landscape shape determined by how interactions between
alleles at different loci change each other’s fitness impact, or epistasis. In
explaining the high amino-acid usage (u), we focused on the global shape of the
fitness landscape, ignoring the perturbations at individual sites.
author:
- first_name: Michael
full_name: Breen, Michael S
last_name: Breen
- first_name: Carsten
full_name: Kemena, Carsten
last_name: Kemena
- first_name: Peter
full_name: Vlasov, Peter K
last_name: Vlasov
- first_name: Cédric
full_name: Notredame, Cédric
last_name: Notredame
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Breen M, Kemena C, Vlasov P, Notredame C, Kondrashov F. Breen et al. reply.
Nature. 2013;497(7451):E2-E3. doi:10.1038/nature12220
apa: Breen, M., Kemena, C., Vlasov, P., Notredame, C., & Kondrashov, F. (2013).
Breen et al. reply. Nature. Nature Publishing Group. https://doi.org/10.1038/nature12220
chicago: Breen, Michael, Carsten Kemena, Peter Vlasov, Cédric Notredame, and Fyodor
Kondrashov. “Breen et Al. Reply.” Nature. Nature Publishing Group, 2013.
https://doi.org/10.1038/nature12220.
ieee: M. Breen, C. Kemena, P. Vlasov, C. Notredame, and F. Kondrashov, “Breen et
al. reply,” Nature, vol. 497, no. 7451. Nature Publishing Group, pp. E2–E3,
2013.
ista: Breen M, Kemena C, Vlasov P, Notredame C, Kondrashov F. 2013. Breen et al.
reply. Nature. 497(7451), E2–E3.
mla: Breen, Michael, et al. “Breen et Al. Reply.” Nature, vol. 497, no. 7451,
Nature Publishing Group, 2013, pp. E2–3, doi:10.1038/nature12220.
short: M. Breen, C. Kemena, P. Vlasov, C. Notredame, F. Kondrashov, Nature 497 (2013)
E2–E3.
date_created: 2018-12-11T11:49:05Z
date_published: 2013-05-30T00:00:00Z
date_updated: 2021-01-12T08:21:40Z
day: '30'
doi: 10.1038/nature12220
extern: 1
intvolume: ' 497'
issue: '7451'
month: '05'
page: E2 - E3
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '6747'
quality_controlled: 0
status: public
title: Breen et al. reply
type: journal_article
volume: 497
year: '2013'
...