--- res: bibo_abstract: - During development, a single cell is transformed into a highly complex organism through progressive cell division, specification and rearrangement. An important prerequisite for the emergence of patterns within the developing organism is to establish asymmetries at various scales, ranging from individual cells to the entire embryo, eventually giving rise to the different body structures. This becomes especially apparent during gastrulation, when the earliest major lineage restriction events lead to the formation of the different germ layers. Traditionally, the unfolding of the developmental program from symmetry breaking to germ layer formation has been studied by dissecting the contributions of different signaling pathways and cellular rearrangements in the in vivo context of intact embryos. Recent efforts, using the intrinsic capacity of embryonic stem cells to self-assemble and generate embryo-like structures de novo, have opened new avenues for understanding the many ways by which an embryo can be built and the influence of extrinsic factors therein. Here, we discuss and compare divergent and conserved strategies leading to germ layer formation in embryos as compared to in vitro systems, their upstream molecular cascades and the role of extrinsic factors in this process.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Alexandra foaf_name: Schauer, Alexandra foaf_surname: Schauer foaf_workInfoHomepage: http://www.librecat.org/personId=30A536BA-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-7659-9142 - foaf_Person: foaf_givenName: Carl-Philipp J foaf_name: Heisenberg, Carl-Philipp J foaf_surname: Heisenberg foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-0912-4566 bibo_doi: 10.1016/j.ydbio.2020.12.014 bibo_volume: 474 dct_date: 2021^xs_gYear dct_identifier: - UT:000639461800008 dct_isPartOf: - http://id.crossref.org/issn/0012-1606 dct_language: eng dct_publisher: Elsevier@ dct_subject: - Developmental Biology - Cell Biology - Molecular Biology dct_title: Reassembling gastrulation@ ...