--- res: bibo_abstract: - Alternative splicing is thought to be a major source of functional diversity in animal proteins. We analyzed the evolutionary conservation of proteins encoded by alternatively spliced genes and predicted the ancestral state for 73 cases of alternative splicing (25 insertions and 48 deletions). The amino acid sequences of most of the inserts in proteins produced by alternative splicing are as conserved as the surrounding sequences. Thus, alternative splicing often creates novel isoforms by the insertion of new, functional protein sequences that probably originated from noncoding sequences of introns.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Fyodor foaf_name: Fyodor Kondrashov foaf_surname: Kondrashov foaf_workInfoHomepage: http://www.librecat.org/personId=44FDEF62-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-8243-4694 - foaf_Person: foaf_givenName: Eugene foaf_name: Koonin, Eugene V foaf_surname: Koonin bibo_doi: 10.1016/S0168-9525(02)00029-X bibo_issue: '3' bibo_volume: 19 dct_date: 2003^xs_gYear dct_publisher: Elsevier@ dct_title: 'Evolution of alternative splicing: Deletions, insertions and origin of functional parts of proteins from intron sequences@' ...