Evolution of alternative splicing: Deletions, insertions and origin of functional parts of proteins from intron sequences

F. Kondrashov, E. Koonin, Trends in Genetics 19 (2003) 115–119.

Download
No fulltext has been uploaded. References only!

Journal Article | Published
Author
Kondrashov, FyodorIST Austria ; Koonin, Eugene V
Abstract
Alternative splicing is thought to be a major source of functional diversity in animal proteins. We analyzed the evolutionary conservation of proteins encoded by alternatively spliced genes and predicted the ancestral state for 73 cases of alternative splicing (25 insertions and 48 deletions). The amino acid sequences of most of the inserts in proteins produced by alternative splicing are as conserved as the surrounding sequences. Thus, alternative splicing often creates novel isoforms by the insertion of new, functional protein sequences that probably originated from noncoding sequences of introns.
Publishing Year
Date Published
2003-01-01
Journal Title
Trends in Genetics
Acknowledgement
We thank Peer Bork, Mikhail Gelfand, Alexey Kondrashov, David Lipman and Shamil Sunyaev for critical reading of the manuscript and useful suggestions and the Koonin group members for helpful discussions.
Volume
19
Issue
3
Page
115 - 119
IST-REx-ID
876

Cite this

Kondrashov F, Koonin E. Evolution of alternative splicing: Deletions, insertions and origin of functional parts of proteins from intron sequences. Trends in Genetics. 2003;19(3):115-119. doi:10.1016/S0168-9525(02)00029-X
Kondrashov, F., & Koonin, E. (2003). Evolution of alternative splicing: Deletions, insertions and origin of functional parts of proteins from intron sequences. Trends in Genetics, 19(3), 115–119. https://doi.org/10.1016/S0168-9525(02)00029-X
Kondrashov, Fyodor, and Eugene Koonin. “Evolution of Alternative Splicing: Deletions, Insertions and Origin of Functional Parts of Proteins from Intron Sequences.” Trends in Genetics 19, no. 3 (2003): 115–19. https://doi.org/10.1016/S0168-9525(02)00029-X.
F. Kondrashov and E. Koonin, “Evolution of alternative splicing: Deletions, insertions and origin of functional parts of proteins from intron sequences,” Trends in Genetics, vol. 19, no. 3, pp. 115–119, 2003.
Kondrashov F, Koonin E. 2003. Evolution of alternative splicing: Deletions, insertions and origin of functional parts of proteins from intron sequences. Trends in Genetics. 19(3), 115–119.
Kondrashov, Fyodor, and Eugene Koonin. “Evolution of Alternative Splicing: Deletions, Insertions and Origin of Functional Parts of Proteins from Intron Sequences.” Trends in Genetics, vol. 19, no. 3, Elsevier, 2003, pp. 115–19, doi:10.1016/S0168-9525(02)00029-X.

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar