Measurements of spontaneous rates of mutations in the recent past and the near future

F. Kondrashov, A. Kondrashov, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 365 (2010) 1169–1176.

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Journal Article | Published
Author
Kondrashov, FyodorIST Austria ; Kondrashov, Alexey S
Abstract
The rate of spontaneous mutation in natural populations is a fundamental parameter for many evolutionary phenomena. Because the rate of mutation is generally low, most of what is currently known about mutation has been obtained through indirect, complex and imprecise methodological approaches. However, in the past few years genome-wide sequencing of closely related individuals has made it possible to estimate the rates of mutation directly at the level of the DNA, avoiding most of the problems associated with using indirect methods. Here, we review the methods used in the past with an emphasis on next generation sequencing, which may soon make the accurate measurement of spontaneous mutation rates a matter of routine.
Publishing Year
Date Published
2010-04-27
Journal Title
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Volume
365
Issue
1544
Page
1169 - 1176
IST-REx-ID
872

Cite this

Kondrashov F, Kondrashov A. Measurements of spontaneous rates of mutations in the recent past and the near future. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences. 2010;365(1544):1169-1176. doi:10.1098/rstb.2009.0286
Kondrashov, F., & Kondrashov, A. (2010). Measurements of spontaneous rates of mutations in the recent past and the near future. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 365(1544), 1169–1176. https://doi.org/10.1098/rstb.2009.0286
Kondrashov, Fyodor, and Alexey Kondrashov. “Measurements of Spontaneous Rates of Mutations in the Recent Past and the near Future.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 365, no. 1544 (2010): 1169–76. https://doi.org/10.1098/rstb.2009.0286.
F. Kondrashov and A. Kondrashov, “Measurements of spontaneous rates of mutations in the recent past and the near future,” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 365, no. 1544, pp. 1169–1176, 2010.
Kondrashov F, Kondrashov A. 2010. Measurements of spontaneous rates of mutations in the recent past and the near future. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 365(1544), 1169–1176.
Kondrashov, Fyodor, and Alexey Kondrashov. “Measurements of Spontaneous Rates of Mutations in the Recent Past and the near Future.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 365, no. 1544, Royal Society, The, 2010, pp. 1169–76, doi:10.1098/rstb.2009.0286.

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