Chaigne, Agathe; Labouesse, Céline; White, Ian J.; Agnew, Meghan; Hannezo, Edouard IST Austria ; Chalut, Kevin J.; Paluch, Ewa K.
Cell fate transitions are key to development and homeostasis. It is thus essential to understand the cellular mechanisms controlling fate transitions. Cell division has been implicated in fate decisions in many stem cell types, including neuronal and epithelial progenitors. In other stem cells, such as embryonic stem (ES) cells, the role of division remains unclear. Here, we show that exit from naive pluripotency in mouse ES cells generally occurs after a division. We further show that exit timing is strongly correlated between sister cells, which remain connected by cytoplasmic bridges long after division, and that bridge abscission progressively accelerates as cells exit naive pluripotency. Finally, interfering with abscission impairs naive pluripotency exit, and artificially inducing abscission accelerates it. Altogether, our data indicate that a switch in the division machinery leading to faster abscission regulates pluripotency exit. Our study identifies abscission as a key cellular process coupling cell division to fate transitions.
Chaigne A, Labouesse C, White IJ, et al. Abscission couples cell division to embryonic stem cell fate. Developmental Cell. doi:10.1016/j.devcel.2020.09.001
Chaigne, A., Labouesse, C., White, I. J., Agnew, M., Hannezo, E. B., Chalut, K. J., & Paluch, E. K. (n.d.). Abscission couples cell division to embryonic stem cell fate. Developmental Cell. https://doi.org/10.1016/j.devcel.2020.09.001
Chaigne, Agathe, Céline Labouesse, Ian J. White, Meghan Agnew, Edouard B Hannezo, Kevin J. Chalut, and Ewa K. Paluch. “Abscission Couples Cell Division to Embryonic Stem Cell Fate.” Developmental Cell, n.d. https://doi.org/10.1016/j.devcel.2020.09.001.
A. Chaigne et al., “Abscission couples cell division to embryonic stem cell fate,” Developmental Cell.
Chaigne A, Labouesse C, White IJ, Agnew M, Hannezo EB, Chalut KJ, Paluch EK. Abscission couples cell division to embryonic stem cell fate. Developmental Cell.
Chaigne, Agathe, et al. “Abscission Couples Cell Division to Embryonic Stem Cell Fate.” Developmental Cell, Elsevier, doi:10.1016/j.devcel.2020.09.001.
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