---
_id: '8669'
abstract:
- lang: eng
text: Pancreatic islets play an essential role in regulating blood glucose level.
Although the molecular pathways underlying islet cell differentiation are beginning
to be resolved, the cellular basis of islet morphogenesis and fate allocation
remain unclear. By combining unbiased and targeted lineage tracing, we address
the events leading to islet formation in the mouse. From the statistical analysis
of clones induced at multiple embryonic timepoints, here we show that, during
the secondary transition, islet formation involves the aggregation of multiple
equipotent endocrine progenitors that transition from a phase of stochastic amplification
by cell division into a phase of sublineage restriction and limited islet fission.
Together, these results explain quantitatively the heterogeneous size distribution
and degree of polyclonality of maturing islets, as well as dispersion of progenitors
within and between islets. Further, our results show that, during the secondary
transition, α- and β-cells are generated in a contemporary manner. Together, these
findings provide insight into the cellular basis of islet development.
article_number: '5037'
article_processing_charge: No
article_type: original
author:
- first_name: Magdalena K.
full_name: Sznurkowska, Magdalena K.
last_name: Sznurkowska
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Roberta
full_name: Azzarelli, Roberta
last_name: Azzarelli
- first_name: Lemonia
full_name: Chatzeli, Lemonia
last_name: Chatzeli
- first_name: Tatsuro
full_name: Ikeda, Tatsuro
last_name: Ikeda
- first_name: Shosei
full_name: Yoshida, Shosei
last_name: Yoshida
- first_name: Anna
full_name: Philpott, Anna
last_name: Philpott
- first_name: Benjamin D
full_name: Simons, Benjamin D
last_name: Simons
citation:
ama: Sznurkowska MK, Hannezo EB, Azzarelli R, et al. Tracing the cellular basis
of islet specification in mouse pancreas. Nature Communications. 2020;11.
doi:10.1038/s41467-020-18837-3
apa: Sznurkowska, M. K., Hannezo, E. B., Azzarelli, R., Chatzeli, L., Ikeda, T.,
Yoshida, S., … Simons, B. D. (2020). Tracing the cellular basis of islet specification
in mouse pancreas. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-020-18837-3
chicago: Sznurkowska, Magdalena K., Edouard B Hannezo, Roberta Azzarelli, Lemonia
Chatzeli, Tatsuro Ikeda, Shosei Yoshida, Anna Philpott, and Benjamin D Simons.
“Tracing the Cellular Basis of Islet Specification in Mouse Pancreas.” Nature
Communications. Springer Nature, 2020. https://doi.org/10.1038/s41467-020-18837-3.
ieee: M. K. Sznurkowska et al., “Tracing the cellular basis of islet specification
in mouse pancreas,” Nature Communications, vol. 11. Springer Nature, 2020.
ista: Sznurkowska MK, Hannezo EB, Azzarelli R, Chatzeli L, Ikeda T, Yoshida S, Philpott
A, Simons BD. 2020. Tracing the cellular basis of islet specification in mouse
pancreas. Nature Communications. 11, 5037.
mla: Sznurkowska, Magdalena K., et al. “Tracing the Cellular Basis of Islet Specification
in Mouse Pancreas.” Nature Communications, vol. 11, 5037, Springer Nature,
2020, doi:10.1038/s41467-020-18837-3.
short: M.K. Sznurkowska, E.B. Hannezo, R. Azzarelli, L. Chatzeli, T. Ikeda, S. Yoshida,
A. Philpott, B.D. Simons, Nature Communications 11 (2020).
date_created: 2020-10-18T22:01:35Z
date_published: 2020-10-07T00:00:00Z
date_updated: 2023-08-22T10:18:17Z
day: '07'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1038/s41467-020-18837-3
external_id:
isi:
- '000577244600003'
pmid:
- '33028844'
file:
- access_level: open_access
checksum: 0ecc0eab72d2d50694852579611a6624
content_type: application/pdf
creator: dernst
date_created: 2020-10-19T11:27:46Z
date_updated: 2020-10-19T11:27:46Z
file_id: '8677'
file_name: 2020_NatureComm_Sznurkowska.pdf
file_size: 5540540
relation: main_file
success: 1
file_date_updated: 2020-10-19T11:27:46Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- '20411723'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tracing the cellular basis of islet specification in mouse pancreas
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2020'
...