---
_id: '8643'
abstract:
- lang: eng
text: The parabigeminal nucleus (PBG) is the mammalian homologue to the isthmic
complex of other vertebrates. Optogenetic stimulation of the PBG induces freezing
and escape in mice, a result thought to be caused by a PBG projection to the central
nucleus of the amygdala. However, the isthmic complex, including the PBG, has
been classically considered satellite nuclei of the Superior Colliculus (SC),
which upon stimulation of its medial part also triggers fear and avoidance reactions.
As the PBG-SC connectivity is not well characterized, we investigated whether
the topology of the PBG projection to the SC could be related to the behavioral
consequences of PBG stimulation. To that end, we performed immunohistochemistry,
in situ hybridization and neural tracer injections in the SC and PBG in a diurnal
rodent, the Octodon degus. We found that all PBG neurons expressed both glutamatergic
and cholinergic markers and were distributed in clearly defined anterior (aPBG)
and posterior (pPBG) subdivisions. The pPBG is connected reciprocally and topographically
to the ipsilateral SC, whereas the aPBG receives afferent axons from the ipsilateral
SC and projected exclusively to the contralateral SC. This contralateral projection
forms a dense field of terminals that is restricted to the medial SC, in correspondence
with the SC representation of the aerial binocular field which, we also found,
in O. degus prompted escape reactions upon looming stimulation. Therefore, this
specialized topography allows binocular interactions in the SC region controlling
responses to aerial predators, suggesting a link between the mechanisms by which
the SC and PBG produce defensive behaviors.
acknowledgement: 'We thank Elisa Sentis and Solano Henriquez for their expert technical
assistance. Dr. David Sterratt for his helpful advice in using the Retistruct package.
Dr. Joao Botelho for his valuable assistance in scanning the retinas. To Mrs. Diane
Greenstein for kindly reading and correcting our manuscript. Macarena Ruiz for her
helpful comments during figures elaboration. Dr. Alexia Nunez-Parra for kindly providing
us with the transgenic mouse line. Dr. Harald Luksch for granting us access to the
confocal microscope at his lab. This study was supported by: FONDECYT 1151432 (to
G.M.), FONDECYT 1170027 (to J.M.) and Doctoral fellowship CONICYT 21161599 (to A.D.).'
article_number: '16220'
article_processing_charge: No
article_type: original
author:
- first_name: Alfonso
full_name: Deichler, Alfonso
last_name: Deichler
- first_name: Denisse
full_name: Carrasco, Denisse
last_name: Carrasco
- first_name: Luciana
full_name: Lopez-Jury, Luciana
last_name: Lopez-Jury
- first_name: Tomas A
full_name: Vega Zuniga, Tomas A
id: 2E7C4E78-F248-11E8-B48F-1D18A9856A87
last_name: Vega Zuniga
- first_name: Natalia
full_name: Marquez, Natalia
last_name: Marquez
- first_name: Jorge
full_name: Mpodozis, Jorge
last_name: Mpodozis
- first_name: Gonzalo
full_name: Marin, Gonzalo
last_name: Marin
citation:
ama: Deichler A, Carrasco D, Lopez-Jury L, et al. A specialized reciprocal connectivity
suggests a link between the mechanisms by which the superior colliculus and parabigeminal
nucleus produce defensive behaviors in rodents. Scientific Reports. 2020;10.
doi:10.1038/s41598-020-72848-0
apa: Deichler, A., Carrasco, D., Lopez-Jury, L., Vega Zuniga, T. A., Marquez, N.,
Mpodozis, J., & Marin, G. (2020). A specialized reciprocal connectivity suggests
a link between the mechanisms by which the superior colliculus and parabigeminal
nucleus produce defensive behaviors in rodents. Scientific Reports. Springer
Nature. https://doi.org/10.1038/s41598-020-72848-0
chicago: Deichler, Alfonso, Denisse Carrasco, Luciana Lopez-Jury, Tomas A Vega Zuniga,
Natalia Marquez, Jorge Mpodozis, and Gonzalo Marin. “A Specialized Reciprocal
Connectivity Suggests a Link between the Mechanisms by Which the Superior Colliculus
and Parabigeminal Nucleus Produce Defensive Behaviors in Rodents.” Scientific
Reports. Springer Nature, 2020. https://doi.org/10.1038/s41598-020-72848-0.
ieee: A. Deichler et al., “A specialized reciprocal connectivity suggests
a link between the mechanisms by which the superior colliculus and parabigeminal
nucleus produce defensive behaviors in rodents,” Scientific Reports, vol.
10. Springer Nature, 2020.
ista: Deichler A, Carrasco D, Lopez-Jury L, Vega Zuniga TA, Marquez N, Mpodozis
J, Marin G. 2020. A specialized reciprocal connectivity suggests a link between
the mechanisms by which the superior colliculus and parabigeminal nucleus produce
defensive behaviors in rodents. Scientific Reports. 10, 16220.
mla: Deichler, Alfonso, et al. “A Specialized Reciprocal Connectivity Suggests a
Link between the Mechanisms by Which the Superior Colliculus and Parabigeminal
Nucleus Produce Defensive Behaviors in Rodents.” Scientific Reports, vol.
10, 16220, Springer Nature, 2020, doi:10.1038/s41598-020-72848-0.
short: A. Deichler, D. Carrasco, L. Lopez-Jury, T.A. Vega Zuniga, N. Marquez, J.
Mpodozis, G. Marin, Scientific Reports 10 (2020).
date_created: 2020-10-11T22:01:14Z
date_published: 2020-10-01T00:00:00Z
date_updated: 2023-08-22T09:58:21Z
day: '01'
ddc:
- '570'
department:
- _id: MaJö
doi: 10.1038/s41598-020-72848-0
external_id:
isi:
- '000577142600032'
file:
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creator: dernst
date_created: 2020-10-12T12:39:10Z
date_updated: 2020-10-12T12:39:10Z
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language:
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oa_version: Published Version
publication: Scientific Reports
publication_identifier:
eissn:
- '20452322'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: A specialized reciprocal connectivity suggests a link between the mechanisms
by which the superior colliculus and parabigeminal nucleus produce defensive behaviors
in rodents
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2020'
...