Optimized fast mixing device for real-time NMR applications

Franco R, Favier A, Schanda P, Brutscher B. 2017. Optimized fast mixing device for real-time NMR applications. Journal of Magnetic Resonance. 281(8), 125–129.

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Journal Article | Published | English
Author
Franco, Rémi; Favier, Adrien; Schanda, PaulIST Austria ; Brutscher, Bernhard
Abstract
We present an improved fast mixing device based on the rapid mixing of two solutions inside the NMR probe, as originally proposed by Hore and coworkers (J. Am. Chem. Soc. 125 (2003) 12484–12492). Such a device is important for off-equilibrium studies of molecular kinetics by multidimensional real-time NMR spectrsocopy. The novelty of this device is that it allows removing the injector from the NMR detection volume after mixing, and thus provides good magnetic field homogeneity independently of the initial sample volume placed in the NMR probe. The apparatus is simple to build, inexpensive, and can be used without any hardware modification on any type of liquid-state NMR spectrometer. We demonstrate the performance of our fast mixing device in terms of improved magnetic field homogeneity, and show an application to the study of protein folding and the structural characterization of transiently populated folding intermediates.
Publishing Year
Date Published
2017-08-01
Journal Title
Journal of Magnetic Resonance
Volume
281
Issue
8
Page
125-129
ISSN
IST-REx-ID

Cite this

Franco R, Favier A, Schanda P, Brutscher B. Optimized fast mixing device for real-time NMR applications. Journal of Magnetic Resonance. 2017;281(8):125-129. doi:10.1016/j.jmr.2017.05.016
Franco, R., Favier, A., Schanda, P., & Brutscher, B. (2017). Optimized fast mixing device for real-time NMR applications. Journal of Magnetic Resonance. Elsevier. https://doi.org/10.1016/j.jmr.2017.05.016
Franco, Rémi, Adrien Favier, Paul Schanda, and Bernhard Brutscher. “Optimized Fast Mixing Device for Real-Time NMR Applications.” Journal of Magnetic Resonance. Elsevier, 2017. https://doi.org/10.1016/j.jmr.2017.05.016.
R. Franco, A. Favier, P. Schanda, and B. Brutscher, “Optimized fast mixing device for real-time NMR applications,” Journal of Magnetic Resonance, vol. 281, no. 8. Elsevier, pp. 125–129, 2017.
Franco R, Favier A, Schanda P, Brutscher B. 2017. Optimized fast mixing device for real-time NMR applications. Journal of Magnetic Resonance. 281(8), 125–129.
Franco, Rémi, et al. “Optimized Fast Mixing Device for Real-Time NMR Applications.” Journal of Magnetic Resonance, vol. 281, no. 8, Elsevier, 2017, pp. 125–29, doi:10.1016/j.jmr.2017.05.016.

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