{"date_published":"2016-07-29T00:00:00Z","abstract":[{"text":"The stimulus selectivity of synaptic currents in cortical neurons often shows a co-tuning of excitation and inhibition, but the mechanisms that underlie the emergence and plasticity of this co-tuning are not fully understood. Using a computational model, we show that an interaction of excitatory and inhibitory synaptic plasticity reproduces both the developmental and – when combined with a disinhibitory gate – the adult plasticity of excitatory and inhibitory receptive fields in auditory cortex. The co-tuning arises from inhibitory plasticity that balances excitation and inhibition, while excitatory stimulus selectivity can result from two different mechanisms. Inhibitory inputs with a broad stimulus tuning introduce a sliding threshold as in Bienenstock-Cooper-Munro rules, introducing an excitatory stimulus selectivity at the cost of a broader inhibitory receptive field. Alternatively, input asymmetries can be amplified by synaptic competition. The latter leaves any receptive field plasticity transient, a prediction we verify in recordings in auditory cortex.","lang":"eng"}],"citation":{"mla":"Clopath, Claudia, et al. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” <i>BioRxiv</i>, Cold Spring Harbor Laboratory, 2016.","short":"C. Clopath, T.P. Vogels, R.C. Froemke, H. Sprekeler, BioRxiv (2016).","ista":"Clopath C, Vogels TP, Froemke RC, Sprekeler H. 2016. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. bioRxiv, .","ieee":"C. Clopath, T. P. Vogels, R. C. Froemke, and H. Sprekeler, “Receptive field formation by interacting excitatory and inhibitory synaptic plasticity,” <i>bioRxiv</i>. Cold Spring Harbor Laboratory, 2016.","chicago":"Clopath, Claudia, Tim P Vogels, Robert C. Froemke, and Henning Sprekeler. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” <i>BioRxiv</i>. Cold Spring Harbor Laboratory, 2016.","apa":"Clopath, C., Vogels, T. P., Froemke, R. C., &#38; Sprekeler, H. (2016). Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. <i>bioRxiv</i>. Cold Spring Harbor Laboratory.","ama":"Clopath C, Vogels TP, Froemke RC, Sprekeler H. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. <i>bioRxiv</i>. 2016."},"date_created":"2020-07-16T12:26:55Z","article_processing_charge":"No","author":[{"full_name":"Clopath, Claudia","last_name":"Clopath","first_name":"Claudia"},{"first_name":"Tim P","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","full_name":"Vogels, Tim P","last_name":"Vogels","orcid":"0000-0003-3295-6181"},{"full_name":"Froemke, Robert C.","last_name":"Froemke","first_name":"Robert C."},{"last_name":"Sprekeler","full_name":"Sprekeler, Henning","first_name":"Henning"}],"month":"07","language":[{"iso":"eng"}],"extern":"1","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","title":"Receptive field formation by interacting excitatory and inhibitory synaptic plasticity","main_file_link":[{"url":"https://doi.org/10.1101/066589 ","open_access":"1"}],"oa":1,"page":"43","year":"2016","publication_status":"published","day":"29","type":"preprint","oa_version":"Preprint","date_updated":"2021-01-12T08:17:02Z","publisher":"Cold Spring Harbor Laboratory","publication":"bioRxiv","_id":"8128","status":"public"}