Receptive field formation by interacting excitatory and inhibitory synaptic plasticity

C. Clopath, T.P. Vogels, R.C. Froemke, H. Sprekeler, BioRxiv (2016).

Preprint | Published | English
Author
Clopath, Claudia; Vogels, Tim PIST Austria; Froemke, Robert C.; Sprekeler, Henning
Abstract
The stimulus selectivity of synaptic currents in cortical neurons often shows a co-tuning of excitation and inhibition, but the mechanisms that underlie the emergence and plasticity of this co-tuning are not fully understood. Using a computational model, we show that an interaction of excitatory and inhibitory synaptic plasticity reproduces both the developmental and – when combined with a disinhibitory gate – the adult plasticity of excitatory and inhibitory receptive fields in auditory cortex. The co-tuning arises from inhibitory plasticity that balances excitation and inhibition, while excitatory stimulus selectivity can result from two different mechanisms. Inhibitory inputs with a broad stimulus tuning introduce a sliding threshold as in Bienenstock-Cooper-Munro rules, introducing an excitatory stimulus selectivity at the cost of a broader inhibitory receptive field. Alternatively, input asymmetries can be amplified by synaptic competition. The latter leaves any receptive field plasticity transient, a prediction we verify in recordings in auditory cortex.
Publishing Year
Date Published
2016-07-29
Journal Title
bioRxiv
Page
43
IST-REx-ID

Cite this

Clopath C, Vogels TP, Froemke RC, Sprekeler H. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. bioRxiv. 2016.
Clopath, C., Vogels, T. P., Froemke, R. C., & Sprekeler, H. (2016). Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. BioRxiv. Cold Spring Harbor Laboratory.
Clopath, Claudia, Tim P Vogels, Robert C. Froemke, and Henning Sprekeler. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” BioRxiv. Cold Spring Harbor Laboratory, 2016.
C. Clopath, T. P. Vogels, R. C. Froemke, and H. Sprekeler, “Receptive field formation by interacting excitatory and inhibitory synaptic plasticity,” bioRxiv. Cold Spring Harbor Laboratory, 2016.
Clopath C, Vogels TP, Froemke RC, Sprekeler H. 2016. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. bioRxiv.
Clopath, Claudia, et al. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” BioRxiv, Cold Spring Harbor Laboratory, 2016.
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