--- res: bibo_abstract: - "Background: The activation of the EGFR/Ras-signalling pathway in tumour cells induces a distinct chemokine repertoire, which in turn modulates the tumour microenvironment.\r\nMethods: The effects of EGFR/Ras on the expression and translation of CCL20 were analysed in a large set of epithelial cancer cell lines and tumour tissues by RT-qPCR and ELISA in vitro. CCL20 production was verified by immunohistochemistry in different tumour tissues and correlated with clinical data. The effects of CCL20 on endothelial cell migration and tumour-associated vascularisation were comprehensively analysed with chemotaxis assays in vitro and in CCR6-deficient mice in vivo.\r\nResults: Tumours facilitate progression by the EGFR/Ras-induced production of CCL20. Expression of the chemokine CCL20 in tumours correlates with advanced tumour stage, increased lymph node metastasis and decreased survival in patients. Microvascular endothelial cells abundantly express the specific CCL20 receptor CCR6. CCR6 signalling in endothelial cells induces angiogenesis. CCR6-deficient mice show significantly decreased tumour growth and tumour-associated vascularisation. The observed phenotype is dependent on CCR6 deficiency in stromal cells but not within the immune system.\r\nConclusion: We propose that the chemokine axis CCL20–CCR6 represents a novel and promising target to interfere with the tumour microenvironment, and opens an innovative multimodal strategy for cancer therapy.@eng" bibo_authorlist: - foaf_Person: foaf_givenName: Andreas foaf_name: Hippe, Andreas foaf_surname: Hippe - foaf_Person: foaf_givenName: Stephan Alexander foaf_name: Braun, Stephan Alexander foaf_surname: Braun - foaf_Person: foaf_givenName: Péter foaf_name: Oláh, Péter foaf_surname: Oláh - foaf_Person: foaf_givenName: Peter Arne foaf_name: Gerber, Peter Arne foaf_surname: Gerber - foaf_Person: foaf_givenName: Anne foaf_name: Schorr, Anne foaf_surname: Schorr - foaf_Person: foaf_givenName: Stephan foaf_name: Seeliger, Stephan foaf_surname: Seeliger - foaf_Person: foaf_givenName: Stephanie foaf_name: Holtz, Stephanie foaf_surname: Holtz - foaf_Person: foaf_givenName: Katharina foaf_name: Jannasch, Katharina foaf_surname: Jannasch - foaf_Person: foaf_givenName: Andor foaf_name: Pivarcsi, Andor foaf_surname: Pivarcsi - foaf_Person: foaf_givenName: Bettina foaf_name: Buhren, Bettina foaf_surname: Buhren - foaf_Person: foaf_givenName: Holger foaf_name: Schrumpf, Holger foaf_surname: Schrumpf - foaf_Person: foaf_givenName: Andreas foaf_name: Kislat, Andreas foaf_surname: Kislat - foaf_Person: foaf_givenName: Erich foaf_name: Bünemann, Erich foaf_surname: Bünemann - foaf_Person: foaf_givenName: Martin foaf_name: Steinhoff, Martin foaf_surname: Steinhoff - foaf_Person: foaf_givenName: Jens foaf_name: Fischer, Jens foaf_surname: Fischer - foaf_Person: foaf_givenName: Sérgio A. foaf_name: Lira, Sérgio A. foaf_surname: Lira - foaf_Person: foaf_givenName: Petra foaf_name: Boukamp, Petra foaf_surname: Boukamp - foaf_Person: foaf_givenName: Peter foaf_name: Hevezi, Peter foaf_surname: Hevezi - foaf_Person: foaf_givenName: Nikolas Hendrik foaf_name: Stoecklein, Nikolas Hendrik foaf_surname: Stoecklein - foaf_Person: foaf_givenName: Thomas foaf_name: Hoffmann, Thomas foaf_surname: Hoffmann - foaf_Person: foaf_givenName: Frauke foaf_name: Alves, Frauke foaf_surname: Alves - foaf_Person: foaf_givenName: Jonathan foaf_name: Sleeman, Jonathan foaf_surname: Sleeman - foaf_Person: foaf_givenName: Thomas foaf_name: Bauer, Thomas foaf_surname: Bauer - foaf_Person: foaf_givenName: Jörg foaf_name: Klufa, Jörg foaf_surname: Klufa - foaf_Person: foaf_givenName: Nicole foaf_name: Amberg, Nicole foaf_surname: Amberg foaf_workInfoHomepage: http://www.librecat.org/personId=4CD6AAC6-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-3183-8207 - foaf_Person: foaf_givenName: Maria foaf_name: Sibilia, Maria foaf_surname: Sibilia - foaf_Person: foaf_givenName: Albert foaf_name: Zlotnik, Albert foaf_surname: Zlotnik - foaf_Person: foaf_givenName: Anja foaf_name: Müller-Homey, Anja foaf_surname: Müller-Homey - foaf_Person: foaf_givenName: Bernhard foaf_name: Homey, Bernhard foaf_surname: Homey bibo_doi: 10.1038/s41416-020-0943-2 bibo_volume: 123 dct_date: 2020^xs_gYear dct_identifier: - UT:000544152500001 dct_isPartOf: - http://id.crossref.org/issn/0007-0920 - http://id.crossref.org/issn/1532-1827 dct_language: eng dct_publisher: Springer Nature@ dct_title: EGFR/Ras-induced CCL20 production modulates the tumour microenvironment@ fabio_hasPubmedId: '32601464' ...