Podlaski, William F; Seeholzer, Alexander; Groschner, Lukas N; Miesenböck, Gero; Ranjan, Rajnish; Vogels, Tim PIST Austria
Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of simulations. However, the number of published models, and the lack of standardization, make the comparison of ion channel models with one another and with experimental data difficult. Here, we present a framework for the automated large-scale classification of ion channel models. Using annotated metadata and responses to a set of voltage-clamp protocols, we assigned 2378 models of voltage- and calcium-gated ion channels coded in NEURON to 211 clusters. The IonChannelGenealogy (ICGenealogy) web interface provides an interactive resource for the categorization of new and existing models and experimental recordings. It enables quantitative comparisons of simulated and/or measured ion channel kinetics, and facilitates field-wide standardization of experimentally-constrained modeling.
Podlaski WF, Seeholzer A, Groschner LN, Miesenböck G, Ranjan R, Vogels TP. Mapping the function of neuronal ion channels in model and experiment. eLife. 2017;6. doi:10.7554/elife.22152
Podlaski, W. F., Seeholzer, A., Groschner, L. N., Miesenböck, G., Ranjan, R., & Vogels, T. P. (2017). Mapping the function of neuronal ion channels in model and experiment. ELife. eLife Sciences Publications, Ltd. https://doi.org/10.7554/elife.22152
Podlaski, William F, Alexander Seeholzer, Lukas N Groschner, Gero Miesenböck, Rajnish Ranjan, and Tim P Vogels. “Mapping the Function of Neuronal Ion Channels in Model and Experiment.” ELife. eLife Sciences Publications, Ltd, 2017. https://doi.org/10.7554/elife.22152.
W. F. Podlaski, A. Seeholzer, L. N. Groschner, G. Miesenböck, R. Ranjan, and T. P. Vogels, “Mapping the function of neuronal ion channels in model and experiment,” eLife, vol. 6. eLife Sciences Publications, Ltd, 2017.
Podlaski WF, Seeholzer A, Groschner LN, Miesenböck G, Ranjan R, Vogels TP. 2017. Mapping the function of neuronal ion channels in model and experiment. eLife. 6, e22152.
Podlaski, William F., et al. “Mapping the Function of Neuronal Ion Channels in Model and Experiment.” ELife, vol. 6, e22152, eLife Sciences Publications, Ltd, 2017, doi:10.7554/elife.22152.
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