Gating multiple signals through detailed balance of excitation and inhibition in spiking networks

T.P. Vogels, L.F. Abbott, Nature Neuroscience 12 (2009) 483–491.


Journal Article | Published | English
Author
Abstract
Recent theoretical work has provided a basic understanding of signal propagation in networks of spiking neurons, but mechanisms for gating and controlling these signals have not been investigated previously. Here we introduce an idea for the gating of multiple signals in cortical networks that combines principles of signal propagation with aspects of balanced networks. Specifically, we studied networks in which incoming excitatory signals are normally cancelled by locally evoked inhibition, leaving the targeted layer unresponsive. Transmission can be gated 'on' by modulating excitatory and inhibitory gains to upset this detailed balance. We illustrate gating through detailed balance in large networks of integrate-and-fire neurons. We show successful gating of multiple signals and study failure modes that produce effects reminiscent of clinically observed pathologies. Provided that the individual signals are detectable, detailed balance has a large capacity for gating multiple signals.
Publishing Year
Date Published
2009-04-01
Journal Title
Nature Neuroscience
Volume
12
Issue
4
Page
483-491
IST-REx-ID

Cite this

Vogels TP, Abbott LF. Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. Nature Neuroscience. 2009;12(4):483-491. doi:10.1038/nn.2276
Vogels, T. P., & Abbott, L. F. (2009). Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. Nature Neuroscience, 12(4), 483–491. https://doi.org/10.1038/nn.2276
Vogels, Tim P, and L F Abbott. “Gating Multiple Signals through Detailed Balance of Excitation and Inhibition in Spiking Networks.” Nature Neuroscience 12, no. 4 (2009): 483–91. https://doi.org/10.1038/nn.2276.
T. P. Vogels and L. F. Abbott, “Gating multiple signals through detailed balance of excitation and inhibition in spiking networks,” Nature Neuroscience, vol. 12, no. 4, pp. 483–491, 2009.
Vogels TP, Abbott LF. 2009. Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. Nature Neuroscience. 12(4), 483–491.
Vogels, Tim P., and L. F. Abbott. “Gating Multiple Signals through Detailed Balance of Excitation and Inhibition in Spiking Networks.” Nature Neuroscience, vol. 12, no. 4, Springer Nature, 2009, pp. 483–91, doi:10.1038/nn.2276.
All files available under the following license(s):
Copyright Statement:
This Item is protected by copyright and/or related rights. [...]

Link(s) to Main File(s)
Access Level
OA Open Access

Export

Marked Publications

Open Data IST Research Explorer

Sources

PMID: 19305402
PubMed | Europe PMC

Search this title in

Google Scholar