Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories

H.C. Barron, T.P. Vogels, U.E. Emir, T.R. Makin, J. O’Shea, S. Clare, S. Jbabdi, R.J. Dolan, T.E.J. Behrens, Neuron 90 (2016) 191–203.

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Journal Article | Published | English
Author
Barron, H.C.; Vogels, Tim PIST Austria; Emir, U.E.; Makin, T.R.; O’Shea, J.; Clare, S.; Jbabdi, S.; Dolan, R.J.; Behrens, T.E.J.
Abstract
Balance of cortical excitation and inhibition (EI) is thought to be disrupted in several neuropsychiatric conditions, yet it is not clear how it is maintained in the healthy human brain. When EI balance is disturbed during learning and memory in animal models, it can be restabilized via formation of inhibitory replicas of newly formed excitatory connections. Here we assess evidence for such selective inhibitory rebalancing in humans. Using fMRI repetition suppression we measure newly formed cortical associations in the human brain. We show that expression of these associations reduces over time despite persistence in behavior, consistent with inhibitory rebalancing. To test this, we modulated excitation/inhibition balance with transcranial direct current stimulation (tDCS). Using ultra-high-field (7T) MRI and spectroscopy, we show that reducing GABA allows cortical associations to be re-expressed. This suggests that in humans associative memories are stored in balanced excitatory-inhibitory ensembles that lie dormant unless latent inhibitory connections are unmasked.
Publishing Year
Date Published
2016-04-06
Journal Title
Neuron
Volume
90
Issue
1
Page
191-203
ISSN
IST-REx-ID

Cite this

Barron HC, Vogels TP, Emir UE, et al. Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories. Neuron. 2016;90(1):191-203. doi:10.1016/j.neuron.2016.02.031
Barron, H. C., Vogels, T. P., Emir, U. E., Makin, T. R., O’Shea, J., Clare, S., … Behrens, T. E. J. (2016). Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories. Neuron, 90(1), 191–203. https://doi.org/10.1016/j.neuron.2016.02.031
Barron, H.C., Tim P Vogels, U.E. Emir, T.R. Makin, J. O’Shea, S. Clare, S. Jbabdi, R.J. Dolan, and T.E.J. Behrens. “Unmasking Latent Inhibitory Connections in Human Cortex to Reveal Dormant Cortical Memories.” Neuron 90, no. 1 (2016): 191–203. https://doi.org/10.1016/j.neuron.2016.02.031.
H. C. Barron et al., “Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories,” Neuron, vol. 90, no. 1, pp. 191–203, 2016.
Barron HC, Vogels TP, Emir UE, Makin TR, O’Shea J, Clare S, Jbabdi S, Dolan RJ, Behrens TEJ. 2016. Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories. Neuron. 90(1), 191–203.
Barron, H. C., et al. “Unmasking Latent Inhibitory Connections in Human Cortex to Reveal Dormant Cortical Memories.” Neuron, vol. 90, no. 1, Elsevier, 2016, pp. 191–203, doi:10.1016/j.neuron.2016.02.031.
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