Inhibitory engrams in perception and memory

H.C. Barron, T.P. Vogels, T.E. Behrens, M. Ramaswami, Proceedings of the National Academy of Sciences 114 (2017) 6666–6674.


Journal Article | Published | English
Author
Barron, Helen C.; Vogels, Tim PIST Austria; Behrens, Timothy E.; Ramaswami, Mani
Abstract
Nervous systems use excitatory cell assemblies to encode and represent sensory percepts. Similarly, synaptically connected cell assemblies or "engrams" are thought to represent memories of past experience. Multiple lines of recent evidence indicate that brain systems create and use inhibitory replicas of excitatory representations for important cognitive functions. Such matched "inhibitory engrams" can form through homeostatic potentiation of inhibition onto postsynaptic cells that show increased levels of excitation. Inhibitory engrams can reduce behavioral responses to familiar stimuli, thereby resulting in behavioral habituation. In addition, by preventing inappropriate activation of excitatory memory engrams, inhibitory engrams can make memories quiescent, stored in a latent form that is available for context-relevant activation. In neural networks with balanced excitatory and inhibitory engrams, the release of innate responses and recall of associative memories can occur through focused disinhibition. Understanding mechanisms that regulate the formation and expression of inhibitory engrams in vivo may help not only to explain key features of cognition but also to provide insight into transdiagnostic traits associated with psychiatric conditions such as autism, schizophrenia, and posttraumatic stress disorder.
Publishing Year
Date Published
2017-06-27
Journal Title
Proceedings of the National Academy of Sciences
Volume
114
Issue
26
Page
6666-6674
ISSN
eISSN
IST-REx-ID

Cite this

Barron HC, Vogels TP, Behrens TE, Ramaswami M. Inhibitory engrams in perception and memory. Proceedings of the National Academy of Sciences. 2017;114(26):6666-6674. doi:10.1073/pnas.1701812114
Barron, H. C., Vogels, T. P., Behrens, T. E., & Ramaswami, M. (2017). Inhibitory engrams in perception and memory. Proceedings of the National Academy of Sciences, 114(26), 6666–6674. https://doi.org/10.1073/pnas.1701812114
Barron, Helen C., Tim P Vogels, Timothy E. Behrens, and Mani Ramaswami. “Inhibitory Engrams in Perception and Memory.” Proceedings of the National Academy of Sciences 114, no. 26 (2017): 6666–74. https://doi.org/10.1073/pnas.1701812114.
H. C. Barron, T. P. Vogels, T. E. Behrens, and M. Ramaswami, “Inhibitory engrams in perception and memory,” Proceedings of the National Academy of Sciences, vol. 114, no. 26, pp. 6666–6674, 2017.
Barron HC, Vogels TP, Behrens TE, Ramaswami M. 2017. Inhibitory engrams in perception and memory. Proceedings of the National Academy of Sciences. 114(26), 6666–6674.
Barron, Helen C., et al. “Inhibitory Engrams in Perception and Memory.” Proceedings of the National Academy of Sciences, vol. 114, no. 26, Proceedings of the National Academy of Sciences, 2017, pp. 6666–74, doi:10.1073/pnas.1701812114.
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