Synaptic transmission optimization predicts expression loci of long-term plasticity

R.P. Costa, Z. Padamsey, J.A. D’Amour, N.J. Emptage, R.C. Froemke, T.P. Vogels, Neuron 96 (2017) 177–189.e7.

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Journal Article | Published | English
Author
Costa, Rui Ponte; Padamsey, Zahid; D’Amour, James A.; Emptage, Nigel J.; Froemke, Robert C.; Vogels, Tim PIST Austria
Abstract
Long-term modifications of neuronal connections are critical for reliable memory storage in the brain. However, their locus of expression—pre- or postsynaptic—is highly variable. Here we introduce a theoretical framework in which long-term plasticity performs an optimization of the postsynaptic response statistics toward a given mean with minimal variance. Consequently, the state of the synapse at the time of plasticity induction determines the ratio of pre- and postsynaptic modifications. Our theory explains the experimentally observed expression loci of the hippocampal and neocortical synaptic potentiation studies we examined. Moreover, the theory predicts presynaptic expression of long-term depression, consistent with experimental observations. At inhibitory synapses, the theory suggests a statistically efficient excitatory-inhibitory balance in which changes in inhibitory postsynaptic response statistics specifically target the mean excitation. Our results provide a unifying theory for understanding the expression mechanisms and functions of long-term synaptic transmission plasticity.
Publishing Year
Date Published
2017-09-27
Journal Title
Neuron
Volume
96
Issue
1
Page
177-189.e7
ISSN
IST-REx-ID

Cite this

Costa RP, Padamsey Z, D’Amour JA, Emptage NJ, Froemke RC, Vogels TP. Synaptic transmission optimization predicts expression loci of long-term plasticity. Neuron. 2017;96(1):177-189.e7. doi:10.1016/j.neuron.2017.09.021
Costa, R. P., Padamsey, Z., D’Amour, J. A., Emptage, N. J., Froemke, R. C., & Vogels, T. P. (2017). Synaptic transmission optimization predicts expression loci of long-term plasticity. Neuron, 96(1), 177–189.e7. https://doi.org/10.1016/j.neuron.2017.09.021
Costa, Rui Ponte, Zahid Padamsey, James A. D’Amour, Nigel J. Emptage, Robert C. Froemke, and Tim P Vogels. “Synaptic Transmission Optimization Predicts Expression Loci of Long-Term Plasticity.” Neuron 96, no. 1 (2017): 177–189.e7. https://doi.org/10.1016/j.neuron.2017.09.021.
R. P. Costa, Z. Padamsey, J. A. D’Amour, N. J. Emptage, R. C. Froemke, and T. P. Vogels, “Synaptic transmission optimization predicts expression loci of long-term plasticity,” Neuron, vol. 96, no. 1, p. 177–189.e7, 2017.
Costa RP, Padamsey Z, D’Amour JA, Emptage NJ, Froemke RC, Vogels TP. 2017. Synaptic transmission optimization predicts expression loci of long-term plasticity. Neuron. 96(1), 177–189.e7.
Costa, Rui Ponte, et al. “Synaptic Transmission Optimization Predicts Expression Loci of Long-Term Plasticity.” Neuron, vol. 96, no. 1, Elsevier, 2017, p. 177–189.e7, doi:10.1016/j.neuron.2017.09.021.
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