{"date_published":"2017-10-02T00:00:00Z","language":[{"iso":"eng"}],"issue":"1","date_created":"2018-12-11T11:48:34Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","external_id":{"isi":["000412053100004"]},"publication_status":"published","title":"Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus","intvolume":"         8","publisher":"Nature Publishing Group","quality_controlled":"1","abstract":[{"lang":"eng","text":"Gamma oscillations (30–150 Hz) in neuronal networks are associated with the processing and recall of information. We measured local field potentials in the dentate gyrus of freely moving mice and found that gamma activity occurs in bursts, which are highly heterogeneous in their spatial extensions, ranging from focal to global coherent events. Synaptic communication among perisomatic-inhibitory interneurons (PIIs) is thought to play an important role in the generation of hippocampal gamma patterns. However, how neuronal circuits can generate synchronous oscillations at different spatial scales is unknown. We analyzed paired recordings in dentate gyrus slices and show that synaptic signaling at interneuron-interneuron synapses is distance dependent. Synaptic strength declines whereas the duration of inhibitory signals increases with axonal distance among interconnected PIIs. Using neuronal network modeling, we show that distance-dependent inhibition generates multiple highly synchronous focal gamma bursts allowing the network to process complex inputs in parallel in flexibly organized neuronal centers."}],"date_updated":"2023-09-27T10:59:41Z","ec_funded":1,"isi":1,"month":"10","publication_identifier":{"issn":["20411723"]},"year":"2017","oa_version":"Published Version","oa":1,"file":[{"file_name":"IST-2017-914-v1+1_s41467-017-00936-3.pdf","access_level":"open_access","date_updated":"2020-07-14T12:48:07Z","relation":"main_file","creator":"system","file_size":4261832,"date_created":"2018-12-12T10:15:17Z","checksum":"7e2c7621afd5f802338e92e8619f024d","content_type":"application/pdf","file_id":"5135"}],"pubrep_id":"914","author":[{"last_name":"Strüber","full_name":"Strüber, Michael","first_name":"Michael"},{"first_name":"Jonas","full_name":"Sauer, Jonas","last_name":"Sauer"},{"last_name":"Jonas","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","full_name":"Jonas, Peter M"},{"last_name":"Bartos","first_name":"Marlene","full_name":"Bartos, Marlene"}],"day":"02","article_processing_charge":"No","doi":"10.1038/s41467-017-00936-3","_id":"800","file_date_updated":"2020-07-14T12:48:07Z","publist_id":"6853","department":[{"_id":"PeJo"}],"type":"journal_article","ddc":["571"],"status":"public","article_number":"758","has_accepted_license":"1","project":[{"grant_number":"268548","_id":"25C0F108-B435-11E9-9278-68D0E5697425","name":"Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons","call_identifier":"FP7"}],"publication":"Nature Communications","scopus_import":"1","volume":8,"citation":{"apa":"Strüber, M., Sauer, J., Jonas, P. M., &#38; Bartos, M. (2017). Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41467-017-00936-3\">https://doi.org/10.1038/s41467-017-00936-3</a>","chicago":"Strüber, Michael, Jonas Sauer, Peter M Jonas, and Marlene Bartos. “Distance-Dependent Inhibition Facilitates Focality of Gamma Oscillations in the Dentate Gyrus.” <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/s41467-017-00936-3\">https://doi.org/10.1038/s41467-017-00936-3</a>.","short":"M. Strüber, J. Sauer, P.M. Jonas, M. Bartos, Nature Communications 8 (2017).","ieee":"M. Strüber, J. Sauer, P. M. Jonas, and M. Bartos, “Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus,” <i>Nature Communications</i>, vol. 8, no. 1. Nature Publishing Group, 2017.","mla":"Strüber, Michael, et al. “Distance-Dependent Inhibition Facilitates Focality of Gamma Oscillations in the Dentate Gyrus.” <i>Nature Communications</i>, vol. 8, no. 1, 758, Nature Publishing Group, 2017, doi:<a href=\"https://doi.org/10.1038/s41467-017-00936-3\">10.1038/s41467-017-00936-3</a>.","ista":"Strüber M, Sauer J, Jonas PM, Bartos M. 2017. Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus. Nature Communications. 8(1), 758.","ama":"Strüber M, Sauer J, Jonas PM, Bartos M. Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus. <i>Nature Communications</i>. 2017;8(1). doi:<a href=\"https://doi.org/10.1038/s41467-017-00936-3\">10.1038/s41467-017-00936-3</a>"},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"}}