--- res: bibo_abstract: - During embryonic and postnatal development, organs and tissues grow steadily to achieve their final size at the end of puberty. However, little is known about the cellular dynamics that mediate postnatal growth. By combining in vivo clonal lineage tracing, proliferation kinetics, single-cell transcriptomics, andin vitro micro-pattern experiments, we resolved the cellular dynamics taking place during postnatal skin epidermis expansion. Our data revealed that harmonious growth is engineered by a single population of developmental progenitors presenting a fixed fate imbalance of self-renewing divisions with an ever-decreasing proliferation rate. Single-cell RNA sequencing revealed that epidermal developmental progenitors form a more uniform population compared with adult stem and progenitor cells. Finally, we found that the spatial pattern of cell division orientation is dictated locally by the underlying collagen fiber orientation. Our results uncover a simple design principle of organ growth where progenitors and differentiated cells expand in harmony with their surrounding tissues.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Sophie foaf_name: Dekoninck, Sophie foaf_surname: Dekoninck - foaf_Person: foaf_givenName: Edouard B foaf_name: Hannezo, Edouard B foaf_surname: Hannezo foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-6005-1561 - foaf_Person: foaf_givenName: Alejandro foaf_name: Sifrim, Alejandro foaf_surname: Sifrim - foaf_Person: foaf_givenName: Yekaterina A. foaf_name: Miroshnikova, Yekaterina A. foaf_surname: Miroshnikova - foaf_Person: foaf_givenName: Mariaceleste foaf_name: Aragona, Mariaceleste foaf_surname: Aragona - foaf_Person: foaf_givenName: Milan foaf_name: Malfait, Milan foaf_surname: Malfait - foaf_Person: foaf_givenName: Souhir foaf_name: Gargouri, Souhir foaf_surname: Gargouri - foaf_Person: foaf_givenName: Charlotte foaf_name: De Neunheuser, Charlotte foaf_surname: De Neunheuser - foaf_Person: foaf_givenName: Christine foaf_name: Dubois, Christine foaf_surname: Dubois - foaf_Person: foaf_givenName: Thierry foaf_name: Voet, Thierry foaf_surname: Voet - foaf_Person: foaf_givenName: Sara A. foaf_name: Wickström, Sara A. foaf_surname: Wickström - foaf_Person: foaf_givenName: Benjamin D. foaf_name: Simons, Benjamin D. foaf_surname: Simons - foaf_Person: foaf_givenName: Cédric foaf_name: Blanpain, Cédric foaf_surname: Blanpain bibo_doi: 10.1016/j.cell.2020.03.015 bibo_issue: '3' bibo_volume: 181 dct_date: 2020^xs_gYear dct_identifier: - UT:000530708400016 dct_isPartOf: - http://id.crossref.org/issn/00928674 - http://id.crossref.org/issn/10974172 dct_language: eng dct_publisher: Elsevier@ dct_title: Defining the design principles of skin epidermis postnatal growth@ fabio_hasPubmedId: '32259486' ...