--- res: bibo_abstract: - 'Genetic association studies in admixed populations are underrepresented in the genomics literature, with a key concern for researchers being the adequate control of spurious associations due to population structure. Linear mixed models (LMMs) are well suited for genome-wide association studies (GWAS) because they account for both population stratification and cryptic relatedness and achieve increased statistical power by jointly modeling all genotyped markers. Additionally, Bayesian LMMs allow for more flexible assumptions about the underlying distribution of genetic effects, and can concurrently estimate the proportion of phenotypic variance explained by genetic markers. Using three recently published Bayesian LMMs, Bayes R, BSLMM, and BOLT-LMM, we investigate an existing data set on eye (n = 625) and skin (n = 684) color from Cape Verde, an island nation off West Africa that is home to individuals with a broad range of phenotypic values for eye and skin color due to the mix of West African and European ancestry. We use simulations to demonstrate the utility of Bayesian LMMs for mapping loci and studying the genetic architecture of quantitative traits in admixed populations. The Bayesian LMMs provide evidence for two new pigmentation loci: one for eye color (AHRR) and one for skin color (DDB1).@eng' bibo_authorlist: - foaf_Person: foaf_givenName: Luke R. foaf_name: Lloyd-Jones, Luke R. foaf_surname: Lloyd-Jones - foaf_Person: foaf_givenName: Matthew Richard foaf_name: Robinson, Matthew Richard foaf_surname: Robinson foaf_workInfoHomepage: http://www.librecat.org/personId=E5D42276-F5DA-11E9-8E24-6303E6697425 orcid: 0000-0001-8982-8813 - foaf_Person: foaf_givenName: Gerhard foaf_name: Moser, Gerhard foaf_surname: Moser - foaf_Person: foaf_givenName: Jian foaf_name: Zeng, Jian foaf_surname: Zeng - foaf_Person: foaf_givenName: Sandra foaf_name: Beleza, Sandra foaf_surname: Beleza - foaf_Person: foaf_givenName: Gregory S. foaf_name: Barsh, Gregory S. foaf_surname: Barsh - foaf_Person: foaf_givenName: Hua foaf_name: Tang, Hua foaf_surname: Tang - foaf_Person: foaf_givenName: Peter M. foaf_name: Visscher, Peter M. foaf_surname: Visscher bibo_doi: 10.1534/genetics.116.193383 bibo_issue: '2' bibo_volume: 206 dct_date: 2017^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/0016-6731 - http://id.crossref.org/issn/1943-2631 dct_language: eng dct_publisher: Genetics Society of America@ dct_title: Inference on the genetic basis of eye and skin color in an admixed population via Bayesian linear mixed models@ ...