Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia

Tucci S, Vohr SH, McCoy RC, Vernot B, Robinson MR, Barbieri C, Nelson BJ, Fu W, Purnomo GA, Sudoyo H, Eichler EE, Barbujani G, Visscher PM, Akey JM, Green RE. 2018. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. Science. 361(6401), 511–516.

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Journal Article | Published | English
Author
Tucci, Serena; Vohr, Samuel H.; McCoy, Rajiv C.; Vernot, Benjamin; Robinson, Matthew RichardIST Austria ; Barbieri, Chiara; Nelson, Brad J.; Fu, Wenqing; Purnomo, Gludhug A.; Sudoyo, Herawati; Eichler, Evan E.; Barbujani, Guido
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Abstract
Flores Island, Indonesia, was inhabited by the small-bodied hominin species Homo floresiensis, which has an unknown evolutionary relationship to modern humans. This island is also home to an extant human pygmy population. Here we describe genome-scale single-nucleotide polymorphism data and whole-genome sequences from a contemporary human pygmy population living on Flores near the cave where H. floresiensis was found. The genomes of Flores pygmies reveal a complex history of admixture with Denisovans and Neanderthals but no evidence for gene flow with other archaic hominins. Modern individuals bear the signatures of recent positive selection encompassing the FADS (fatty acid desaturase) gene cluster, likely related to diet, and polygenic selection acting on standing variation that contributed to their short-stature phenotype. Thus, multiple independent instances of hominin insular dwarfism occurred on Flores.
Publishing Year
Date Published
2018-08-03
Journal Title
Science
Volume
361
Issue
6401
Page
511-516
IST-REx-ID

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Tucci S, Vohr SH, McCoy RC, et al. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. Science. 2018;361(6401):511-516. doi:10.1126/science.aar8486
Tucci, S., Vohr, S. H., McCoy, R. C., Vernot, B., Robinson, M. R., Barbieri, C., … Green, R. E. (2018). Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aar8486
Tucci, Serena, Samuel H. Vohr, Rajiv C. McCoy, Benjamin Vernot, Matthew Richard Robinson, Chiara Barbieri, Brad J. Nelson, et al. “Evolutionary History and Adaptation of a Human Pygmy Population of Flores Island, Indonesia.” Science. American Association for the Advancement of Science, 2018. https://doi.org/10.1126/science.aar8486.
S. Tucci et al., “Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia,” Science, vol. 361, no. 6401. American Association for the Advancement of Science, pp. 511–516, 2018.
Tucci S, Vohr SH, McCoy RC, Vernot B, Robinson MR, Barbieri C, Nelson BJ, Fu W, Purnomo GA, Sudoyo H, Eichler EE, Barbujani G, Visscher PM, Akey JM, Green RE. 2018. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. Science. 361(6401), 511–516.
Tucci, Serena, et al. “Evolutionary History and Adaptation of a Human Pygmy Population of Flores Island, Indonesia.” Science, vol. 361, no. 6401, American Association for the Advancement of Science, 2018, pp. 511–16, doi:10.1126/science.aar8486.

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PMID: 30072539
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