[{"language":[{}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-019-13225-y"}],"oa":1,"quality_controlled":"1","month":"11","publication_identifier":{"issn":[]},"author":[{"first_name":"Olivier","last_name":"Delaneau"},{"last_name":"Zagury","first_name":"Jean-François"},{"first_name":"Matthew Richard","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","orcid":"0000-0001-8982-8813"},{"first_name":"Jonathan L.","last_name":"Marchini"},{"last_name":"Dermitzakis","first_name":"Emmanouil T."}],"date_updated":"2021-01-12T08:15:01Z","dini_type":"doc-type:article","date_created":"2020-04-30T10:40:32Z","volume":10,"publication_status":"published","extern":"1","creator":{"login":"dernst","id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},"article_number":"5436","date_published":"2019-11-28T00:00:00Z","publication":"Nature Communications","citation":{"short":"O. Delaneau, J.-F. Zagury, M.R. Robinson, J.L. Marchini, E.T. Dermitzakis, Nature Communications 10 (2019).","mla":"Delaneau, Olivier, et al. “Accurate, Scalable and Integrative Haplotype Estimation.” Nature Communications, vol. 10, 5436, Springer Nature, 2019, doi:10.1038/s41467-019-13225-y.","chicago":"Delaneau, Olivier, Jean-François Zagury, Matthew Richard Robinson, Jonathan L. Marchini, and Emmanouil T. Dermitzakis. “Accurate, Scalable and Integrative Haplotype Estimation.” Nature Communications. Springer Nature, 2019. https://doi.org/10.1038/s41467-019-13225-y.","apa":"Delaneau, O., Zagury, J.-F., Robinson, M. R., Marchini, J. L., & Dermitzakis, E. T. (2019). Accurate, scalable and integrative haplotype estimation. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-019-13225-y","ieee":"O. Delaneau, J.-F. Zagury, M. R. Robinson, J. L. Marchini, and E. T. Dermitzakis, “Accurate, scalable and integrative haplotype estimation,” Nature Communications, vol. 10. Springer Nature, 2019.","ista":"Delaneau O, Zagury J-F, Robinson MR, Marchini JL, Dermitzakis ET. 2019. Accurate, scalable and integrative haplotype estimation. Nature Communications. 10, 5436."},"article_type":"original","day":"28","uri_base":"https://research-explorer.ista.ac.at","article_processing_charge":"No","dc":{"creator":["Delaneau, Olivier","Zagury, Jean-François","Robinson, Matthew Richard","Marchini, Jonathan L.","Dermitzakis, Emmanouil T."],"description":["The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount of data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing datasets. It notably exhibits sub-linear running times with sample size, provides highly accurate haplotypes and allows integrating external phasing information such as large reference panels of haplotypes, collections of pre-phased variants and long sequencing reads. We provide SHAPEIT4 in an open source format and demonstrate its performance in terms of accuracy and running times on two gold standard datasets: the UK Biobank data and the Genome In A Bottle."],"identifier":["https://research-explorer.ista.ac.at/record/7710"],"type":["info:eu-repo/semantics/article","doc-type:article","text","http://purl.org/coar/resource_type/c_6501"],"language":["eng"],"date":["2019"],"publisher":["Springer Nature"],"relation":["info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-019-13225-y","info:eu-repo/semantics/altIdentifier/issn/2041-1723"],"title":["Accurate, scalable and integrative haplotype estimation"],"rights":["info:eu-repo/semantics/openAccess"],"source":["Delaneau O, Zagury J-F, Robinson MR, Marchini JL, Dermitzakis ET. Accurate, scalable and integrative haplotype estimation. Nature Communications. 2019;10. doi:10.1038/s41467-019-13225-y"]},"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"7710","status":"public","intvolume":" 10","abstract":[{"lang":"eng"}],"type":"journal_article"}]