Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons

Komiyama T, Sweeney LBJ, Schuldiner O, Garcia KC, Luo L. 2007. Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons. Cell. 128(2), 399–410.

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Journal Article | Published | English
Author
Komiyama, Takaki; Sweeney, Lora B.IST Austria; Schuldiner, Oren; Garcia, K. Christopher; Luo, Liqun
Abstract
Gradients of axon guidance molecules instruct the formation of continuous neural maps, such as the retinotopic map in the vertebrate visual system. Here we show that molecular gradients can also instruct the formation of a discrete neural map. In the fly olfactory system, axons of 50 classes of olfactory receptor neurons (ORNs) and dendrites of 50 classes of projection neurons (PNs) form one-to-one connections at discrete units called glomeruli. We provide expression, loss- and gain-of-function data to demonstrate that the levels of transmembrane Semaphorin-1a (Sema-1a), acting cell-autonomously as a receptor or part of a receptor complex, direct the dendritic targeting of PNs along the dorsolateral to ventromedial axis of the antennal lobe. Sema-1a also regulates PN axon targeting in higher olfactory centers. Thus, graded expression of Sema-1a contributes to connection specificity from ORNs to PNs and then to higher brain centers, ensuring proper representation of olfactory information in the brain.
Publishing Year
Date Published
2007-01-26
Journal Title
Cell
Volume
128
Issue
2
Page
399-410
ISSN
IST-REx-ID

Cite this

Komiyama T, Sweeney LBJ, Schuldiner O, Garcia KC, Luo L. Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons. Cell. 2007;128(2):399-410. doi:10.1016/j.cell.2006.12.028
Komiyama, T., Sweeney, L. B. J., Schuldiner, O., Garcia, K. C., & Luo, L. (2007). Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons. Cell. Elsevier. https://doi.org/10.1016/j.cell.2006.12.028
Komiyama, Takaki, Lora Beatrice Jaeger Sweeney, Oren Schuldiner, K. Christopher Garcia, and Liqun Luo. “Graded Expression of Semaphorin-1a Cell-Autonomously Directs Dendritic Targeting of Olfactory Projection Neurons.” Cell. Elsevier, 2007. https://doi.org/10.1016/j.cell.2006.12.028.
T. Komiyama, L. B. J. Sweeney, O. Schuldiner, K. C. Garcia, and L. Luo, “Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons,” Cell, vol. 128, no. 2. Elsevier, pp. 399–410, 2007.
Komiyama T, Sweeney LBJ, Schuldiner O, Garcia KC, Luo L. 2007. Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons. Cell. 128(2), 399–410.
Komiyama, Takaki, et al. “Graded Expression of Semaphorin-1a Cell-Autonomously Directs Dendritic Targeting of Olfactory Projection Neurons.” Cell, vol. 128, no. 2, Elsevier, 2007, pp. 399–410, doi:10.1016/j.cell.2006.12.028.

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