A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS

Z. Wu, L.B.J. Sweeney, J.C. Ayoob, K. Chak, B.J. Andreone, T. Ohyama, R. Kerr, L. Luo, M. Zlatic, A.L. Kolodkin, Neuron 70 (2011) 281–298.

Download
No fulltext has been uploaded. References only!

Journal Article | Published | English
Author
Wu, Zhuhao; Sweeney, Lora B.IST Austria; Ayoob, Joseph C.; Chak, Kayam; Andreone, Benjamin J.; Ohyama, Tomoko; Kerr, Rex; Luo, Liqun; Zlatic, Marta; Kolodkin, Alex L.
Abstract
Longitudinal axon fascicles within the Drosophila embryonic CNS provide connections between body segments and are required for coordinated neural signaling along the anterior-posterior axis. We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B (PlexB), but serve distinct guidance functions. Localized Sema-2b attraction promotes the initial assembly of a subset of CNS longitudinal projections and subsequent targeting of chordotonal sensory afferent axons to these same longitudinal connectives, whereas broader Sema-2a repulsion serves to prevent aberrant innervation. In the absence of Sema-2b or PlexB, chordotonal afferent connectivity within the CNS is severely disrupted, resulting in specific larval behavioral deficits. These results reveal that distinct semaphorin-mediated guidance functions converge at PlexB and are critical for functional neural circuit assembly.
Publishing Year
Date Published
2011-04-28
Journal Title
Neuron
Volume
70
Issue
2
Page
281-298
ISSN
IST-REx-ID

Cite this

Wu Z, Sweeney LBJ, Ayoob JC, et al. A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS. Neuron. 2011;70(2):281-298. doi:10.1016/j.neuron.2011.02.050
Wu, Z., Sweeney, L. B. J., Ayoob, J. C., Chak, K., Andreone, B. J., Ohyama, T., … Kolodkin, A. L. (2011). A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2011.02.050
Wu, Zhuhao, Lora Beatrice Jaeger Sweeney, Joseph C. Ayoob, Kayam Chak, Benjamin J. Andreone, Tomoko Ohyama, Rex Kerr, Liqun Luo, Marta Zlatic, and Alex L. Kolodkin. “A Combinatorial Semaphorin Code Instructs the Initial Steps of Sensory Circuit Assembly in the Drosophila CNS.” Neuron. Elsevier, 2011. https://doi.org/10.1016/j.neuron.2011.02.050.
Z. Wu et al., “A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS,” Neuron, vol. 70, no. 2. Elsevier, pp. 281–298, 2011.
Wu Z, Sweeney LBJ, Ayoob JC, Chak K, Andreone BJ, Ohyama T, Kerr R, Luo L, Zlatic M, Kolodkin AL. 2011. A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS. Neuron. 70(2), 281–298.
Wu, Zhuhao, et al. “A Combinatorial Semaphorin Code Instructs the Initial Steps of Sensory Circuit Assembly in the Drosophila CNS.” Neuron, vol. 70, no. 2, Elsevier, 2011, pp. 281–98, doi:10.1016/j.neuron.2011.02.050.

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar