Origin and segmental diversity of spinal inhibitory interneurons

L.B.J. Sweeney, J.B. Bikoff, M.I. Gabitto, S. Brenner-Morton, M. Baek, J.H. Yang, E.G. Tabak, J.S. Dasen, C.R. Kintner, T.M. Jessell, Neuron 97 (2018) 341–355.e3.

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Journal Article | Published | English
Author
Sweeney, Lora B.IST Austria; Bikoff, Jay B.; Gabitto, Mariano I.; Brenner-Morton, Susan; Baek, Myungin; Yang, Jerry H.; Tabak, Esteban G.; Dasen, Jeremy S.; Kintner, Christopher R.; Jessell, Thomas M.
Abstract
Motor output varies along the rostro-caudal axis of the tetrapod spinal cord. At limb levels, ∼60 motor pools control the alternation of flexor and extensor muscles about each joint, whereas at thoracic levels as few as 10 motor pools supply muscle groups that support posture, inspiration, and expiration. Whether such differences in motor neuron identity and muscle number are associated with segmental distinctions in interneuron diversity has not been resolved. We show that select combinations of nineteen transcription factors that specify lumbar V1 inhibitory interneurons generate subpopulations enriched at limb and thoracic levels. Specification of limb and thoracic V1 interneurons involves the Hox gene Hoxc9 independently of motor neurons. Thus, early Hox patterning of the spinal cord determines the identity of V1 interneurons and motor neurons. These studies reveal a developmental program of V1 interneuron diversity, providing insight into the organization of inhibitory interneurons associated with differential motor output.
Publishing Year
Date Published
2018-01-04
Journal Title
Neuron
Volume
97
Issue
2
Page
341-355.e3
ISSN
IST-REx-ID

Cite this

Sweeney LBJ, Bikoff JB, Gabitto MI, et al. Origin and segmental diversity of spinal inhibitory interneurons. Neuron. 2018;97(2):341-355.e3. doi:10.1016/j.neuron.2017.12.029
Sweeney, L. B. J., Bikoff, J. B., Gabitto, M. I., Brenner-Morton, S., Baek, M., Yang, J. H., … Jessell, T. M. (2018). Origin and segmental diversity of spinal inhibitory interneurons. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2017.12.029
Sweeney, Lora Beatrice Jaeger, Jay B. Bikoff, Mariano I. Gabitto, Susan Brenner-Morton, Myungin Baek, Jerry H. Yang, Esteban G. Tabak, Jeremy S. Dasen, Christopher R. Kintner, and Thomas M. Jessell. “Origin and Segmental Diversity of Spinal Inhibitory Interneurons.” Neuron. Elsevier, 2018. https://doi.org/10.1016/j.neuron.2017.12.029.
L. B. J. Sweeney et al., “Origin and segmental diversity of spinal inhibitory interneurons,” Neuron, vol. 97, no. 2. Elsevier, p. 341–355.e3, 2018.
Sweeney LBJ, Bikoff JB, Gabitto MI, Brenner-Morton S, Baek M, Yang JH, Tabak EG, Dasen JS, Kintner CR, Jessell TM. 2018. Origin and segmental diversity of spinal inhibitory interneurons. Neuron. 97(2), 341–355.e3.
Sweeney, Lora Beatrice Jaeger, et al. “Origin and Segmental Diversity of Spinal Inhibitory Interneurons.” Neuron, vol. 97, no. 2, Elsevier, 2018, p. 341–355.e3, doi:10.1016/j.neuron.2017.12.029.

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