Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron

J.A. Cohn, E.R. Cebul, G. Valperga, L. Brose, M. de Bono, M.G. Heiman, J.T. Pierce, Developmental Biology (n.d.).


Journal Article | In Press | English
Author
Cohn, Jesse A.; Cebul, Elizabeth R.; Valperga, Giulio; Brose, Lotti; de Bono, MarioIST Austria ; Heiman, Maxwell G.; Pierce, Jonathan T.
Abstract
Neuronal activity often leads to alterations in gene expression and cellular architecture. The nematode Caenorhabditis elegans, owing to its compact translucent nervous system, is a powerful system in which to study conserved aspects of the development and plasticity of neuronal morphology. Here we focus on one pair of sensory neurons, termed URX, which the worm uses to sense and avoid high levels of environmental oxygen. Previous studies have reported that the URX neuron pair has variable branched endings at its dendritic sensory tip. By controlling oxygen levels and analyzing mutants, we found that these microtubule-rich branched endings grow over time as a consequence of neuronal activity in adulthood. We also find that the growth of these branches correlates with an increase in cellular sensitivity to particular ranges of oxygen that is observable in the behavior of older worms. Given the strengths of C. elegans as a model organism, URX may serve as a potent system for uncovering genes and mechanisms involved in activity-dependent morphological changes in neurons and possible adaptive changes in the aging nervous system.
Publishing Year
Date Published
2020-01-13
Journal Title
Developmental Biology
ISSN
IST-REx-ID

Cite this

Cohn JA, Cebul ER, Valperga G, et al. Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron. Developmental Biology. doi:10.1016/j.ydbio.2020.01.005
Cohn, J. A., Cebul, E. R., Valperga, G., Brose, L., de Bono, M., Heiman, M. G., & Pierce, J. T. (n.d.). Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron. Developmental Biology. https://doi.org/10.1016/j.ydbio.2020.01.005
Cohn, Jesse A., Elizabeth R. Cebul, Giulio Valperga, Lotti Brose, Mario de Bono, Maxwell G. Heiman, and Jonathan T. Pierce. “Long-Term Activity Drives Dendritic Branch Elaboration of a C. Elegans Sensory Neuron.” Developmental Biology, n.d. https://doi.org/10.1016/j.ydbio.2020.01.005.
J. A. Cohn et al., “Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron,” Developmental Biology.
Cohn JA, Cebul ER, Valperga G, Brose L, de Bono M, Heiman MG, Pierce JT. Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron. Developmental Biology.
Cohn, Jesse A., et al. “Long-Term Activity Drives Dendritic Branch Elaboration of a C. Elegans Sensory Neuron.” Developmental Biology, Elsevier, doi:10.1016/j.ydbio.2020.01.005.
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