{"status":"public","title":"Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states","extern":"1","date_published":"2019-08-01T00:00:00Z","date_created":"2020-02-11T08:43:49Z","oa_version":"Submitted Version","article_type":"original","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["1465-7392","1476-4679"]},"type":"journal_article","month":"08","abstract":[{"text":"The sebaceous gland (SG) is an essential component of the skin, and SG dysfunction is debilitating1,2. Yet, the cellular bases for its origin, development and subsequent maintenance remain poorly understood. Here, we apply large-scale quantitative fate mapping to define the patterns of cell fate behaviour during SG development and maintenance. We show that the SG develops from a defined number of lineage-restricted progenitors that undergo a programme of independent and stochastic cell fate decisions. Following an expansion phase, equipotent progenitors transition into a phase of homeostatic turnover, which is correlated with changes in the mechanical properties of the stroma and spatial restrictions on gland size. Expression of the oncogene KrasG12D results in a release from these constraints and unbridled gland expansion. Quantitative clonal fate analysis reveals that, during this phase, the primary effect of the Kras oncogene is to drive a constant fate bias with little effect on cell division rates. These findings provide insight into the developmental programme of the SG, as well as the mechanisms that drive tumour progression and gland dysfunction.","lang":"eng"}],"quality_controlled":"1","pmid":1,"citation":{"chicago":"Andersen, Marianne Stemann, Edouard B Hannezo, Svetlana Ulyanchenko, Soline Estrach, Yasuko Antoku, Sabrina Pisano, Kim E. Boonekamp, et al. “Tracing the Cellular Dynamics of Sebaceous Gland Development in Normal and Perturbed States.” <i>Nature Cell Biology</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41556-019-0362-x\">https://doi.org/10.1038/s41556-019-0362-x</a>.","ieee":"M. S. Andersen <i>et al.</i>, “Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states,” <i>Nature Cell Biology</i>, vol. 21, no. 8. Springer Nature, pp. 924–932, 2019.","apa":"Andersen, M. S., Hannezo, E. B., Ulyanchenko, S., Estrach, S., Antoku, Y., Pisano, S., … Jensen, K. B. (2019). Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states. <i>Nature Cell Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41556-019-0362-x\">https://doi.org/10.1038/s41556-019-0362-x</a>","mla":"Andersen, Marianne Stemann, et al. “Tracing the Cellular Dynamics of Sebaceous Gland Development in Normal and Perturbed States.” <i>Nature Cell Biology</i>, vol. 21, no. 8, Springer Nature, 2019, pp. 924–32, doi:<a href=\"https://doi.org/10.1038/s41556-019-0362-x\">10.1038/s41556-019-0362-x</a>.","ista":"Andersen MS, Hannezo EB, Ulyanchenko S, Estrach S, Antoku Y, Pisano S, Boonekamp KE, Sendrup S, Maimets M, Pedersen MT, Johansen JV, Clement DL, Feral CC, Simons BD, Jensen KB. 2019. Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states. Nature Cell Biology. 21(8), 924–932.","short":"M.S. Andersen, E.B. Hannezo, S. Ulyanchenko, S. Estrach, Y. Antoku, S. Pisano, K.E. Boonekamp, S. Sendrup, M. Maimets, M.T. Pedersen, J.V. Johansen, D.L. Clement, C.C. Feral, B.D. Simons, K.B. Jensen, Nature Cell Biology 21 (2019) 924–932.","ama":"Andersen MS, Hannezo EB, Ulyanchenko S, et al. Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states. <i>Nature Cell Biology</i>. 2019;21(8):924-932. doi:<a href=\"https://doi.org/10.1038/s41556-019-0362-x\">10.1038/s41556-019-0362-x</a>"},"intvolume":"        21","author":[{"last_name":"Andersen","full_name":"Andersen, Marianne Stemann","first_name":"Marianne Stemann"},{"last_name":"Hannezo","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6005-1561","first_name":"Edouard B"},{"full_name":"Ulyanchenko, Svetlana","last_name":"Ulyanchenko","first_name":"Svetlana"},{"full_name":"Estrach, Soline","last_name":"Estrach","first_name":"Soline"},{"last_name":"Antoku","full_name":"Antoku, Yasuko","first_name":"Yasuko"},{"last_name":"Pisano","full_name":"Pisano, Sabrina","first_name":"Sabrina"},{"last_name":"Boonekamp","full_name":"Boonekamp, Kim E.","first_name":"Kim E."},{"last_name":"Sendrup","full_name":"Sendrup, Sarah","first_name":"Sarah"},{"full_name":"Maimets, Martti","last_name":"Maimets","first_name":"Martti"},{"first_name":"Marianne Terndrup","last_name":"Pedersen","full_name":"Pedersen, Marianne Terndrup"},{"first_name":"Jens V.","full_name":"Johansen, Jens V.","last_name":"Johansen"},{"full_name":"Clement, Ditte L.","last_name":"Clement","first_name":"Ditte L."},{"first_name":"Chloe C.","last_name":"Feral","full_name":"Feral, Chloe C."},{"first_name":"Benjamin D.","last_name":"Simons","full_name":"Simons, Benjamin D."},{"first_name":"Kim B.","last_name":"Jensen","full_name":"Jensen, Kim B."}],"external_id":{"pmid":["31358966"]},"publication_status":"published","language":[{"iso":"eng"}],"oa":1,"day":"01","publisher":"Springer Nature","volume":21,"year":"2019","publication":"Nature Cell Biology","_id":"7476","date_updated":"2021-01-12T08:13:47Z","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978139/","open_access":"1"}],"page":"924-932","doi":"10.1038/s41556-019-0362-x","issue":"8"}