Coordination of morphogenesis and cell fate specification in development

C. Chan, C.-P.J. Heisenberg, T. Hiiragi, Current Biology 27 (2017) R1024–R1035.

Download
No fulltext has been uploaded. References only!

Journal Article | Published | English
Author
; ;
Department
Abstract
During animal development, cell-fate-specific changes in gene expression can modify the material properties of a tissue and drive tissue morphogenesis. While mechanistic insights into the genetic control of tissue-shaping events are beginning to emerge, how tissue morphogenesis and mechanics can reciprocally impact cell-fate specification remains relatively unexplored. Here we review recent findings reporting how multicellular morphogenetic events and their underlying mechanical forces can feed back into gene regulatory pathways to specify cell fate. We further discuss emerging techniques that allow for the direct measurement and manipulation of mechanical signals in vivo, offering unprecedented access to study mechanotransduction during development. Examination of the mechanical control of cell fate during tissue morphogenesis will pave the way to an integrated understanding of the design principles that underlie robust tissue patterning in embryonic development.
Publishing Year
Date Published
2017-09-18
Journal Title
Current Biology
Volume
27
Issue
18
Page
R1024 - R1035
ISSN
IST-REx-ID

Cite this

Chan C, Heisenberg C-PJ, Hiiragi T. Coordination of morphogenesis and cell fate specification in development. Current Biology. 2017;27(18):R1024-R1035. doi:10.1016/j.cub.2017.07.010
Chan, C., Heisenberg, C.-P. J., & Hiiragi, T. (2017). Coordination of morphogenesis and cell fate specification in development. Current Biology, 27(18), R1024–R1035. https://doi.org/10.1016/j.cub.2017.07.010
Chan, Chii, Carl-Philipp J Heisenberg, and Takashi Hiiragi. “Coordination of Morphogenesis and Cell Fate Specification in Development.” Current Biology 27, no. 18 (2017): R1024–35. https://doi.org/10.1016/j.cub.2017.07.010.
C. Chan, C.-P. J. Heisenberg, and T. Hiiragi, “Coordination of morphogenesis and cell fate specification in development,” Current Biology, vol. 27, no. 18, pp. R1024–R1035, 2017.
Chan C, Heisenberg C-PJ, Hiiragi T. 2017. Coordination of morphogenesis and cell fate specification in development. Current Biology. 27(18), R1024–R1035.
Chan, Chii, et al. “Coordination of Morphogenesis and Cell Fate Specification in Development.” Current Biology, vol. 27, no. 18, Cell Press, 2017, pp. R1024–35, doi:10.1016/j.cub.2017.07.010.

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar