Data for the paper "Gene amplification as a form of population-level gene expression regulation"

I. Tomanek, Data for the Paper “Gene Amplification as a Form of Population-Level Gene Expression Regulation,” IST Austria, 2019.

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Department
Abstract
Organisms cope with change by employing transcriptional regulators. However, when faced with rare environments, the evolution of transcriptional regulators and their promoters may be too slow. We ask whether the intrinsic instability of gene duplication and amplification provides a generic alternative to canonical gene regulation. By real-time monitoring of gene copy number mutations in E. coli, we show that gene duplications and amplifications enable adaptation to fluctuating environments by rapidly generating copy number, and hence expression level, polymorphism. This ‘amplification-mediated gene expression tuning’ occurs on timescales similar to canonical gene regulation and can deal with rapid environmental changes. Mathematical modeling shows that amplifications also tune gene expression in stochastic environments where transcription factor-based schemes are hard to evolve or maintain. The fleeting nature of gene amplifications gives rise to a generic population-level mechanism that relies on genetic heterogeneity to rapidly tune expression of any gene, without leaving any genomic signature.
Publishing Year
Date Published
2019-11-13
Data Re-Use License
IST-REx-ID

Cite this

Tomanek I. Data for the Paper “Gene Amplification as a Form of Population-Level Gene Expression Regulation.” IST Austria; 2019. doi:10.15479/AT:ISTA:7016
Tomanek, I. (2019). Data for the paper “Gene amplification as a form of population-level gene expression regulation.” IST Austria. https://doi.org/10.15479/AT:ISTA:7016
Tomanek, Isabella. Data for the Paper “Gene Amplification as a Form of Population-Level Gene Expression Regulation.” IST Austria, 2019. https://doi.org/10.15479/AT:ISTA:7016.
I. Tomanek, Data for the paper “Gene amplification as a form of population-level gene expression regulation.” IST Austria, 2019.
Tomanek I. 2019. Data for the paper ‘Gene amplification as a form of population-level gene expression regulation’, IST Austria,p.
Tomanek, Isabella. Data for the Paper “Gene Amplification as a Form of Population-Level Gene Expression Regulation.” IST Austria, 2019, doi:10.15479/AT:ISTA:7016.
All files available under the following license(s):
Data Re-Use License:All Rights Reserved
Main File(s)
File Name
File Title
Locus1_amplified
Description
Illumina whole genome sequence data for Locus 1 - amplified.
Access Level
OA Open Access
Last Uploaded
2020-01-09T12:20:40Z
File Name
File Title
Locus1_ancestral
Description
Illumina whole genome sequence data for Locus 1 - ancestral.
Access Level
OA Open Access
Last Uploaded
2020-01-09T12:20:40Z
File Name
File Title
Locus1_amplified_DOG
Description
Illumina whole genome sequence data for Locus 1 - amplified, after DOG-selection.
Access Level
OA Open Access
Last Uploaded
2020-01-09T12:20:40Z
File Name
File Title
Locus2_amplified
Description
Illumina whole genome sequence data for Locus 2 - amplified.
Access Level
OA Open Access
Last Uploaded
2020-01-09T12:20:40Z
File Name
File Title
Locus2_ancestral
Description
Illumina whole genome sequence data for Locus 2 - ancestral.
Access Level
OA Open Access
Last Uploaded
2020-01-09T12:20:40Z
File Name
File Title
Locus2_amplified_DOG
Description
Illumina whole genome sequence data for Locus 2 - amplified, after DOG-selection.
Access Level
OA Open Access
Last Uploaded
2020-01-09T12:20:40Z
File Title
DNA sequence of the chromosomal reporter gene cassette
Description
Compressed genbank file format containing the sequence of the chromosomal reporter gene cassette.
Access Level
OA Open Access
Last Uploaded
2020-01-14T11:22:27Z
File Name
File Title
Read_me_sequence_data
Access Level
OA Open Access
Last Uploaded
2020-01-22T09:57:55Z
File Name
File Title
FACS data
Description
FACS data associated with Fig. 2c - see read_me_FACS
Access Level
OA Open Access
Last Uploaded
2020-01-22T15:44:16Z
File Name
Access Level
OA Open Access
Last Uploaded
2020-01-22T15:44:16Z
File Name
Access Level
OA Open Access
Last Uploaded
2020-01-22T15:44:16Z
File Name
File Title
microfluidics data
Description
microfluidics time trace data - see read_me_microfluidics
Access Level
OA Open Access
Last Uploaded
2020-01-22T15:44:17Z


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