{"status":"public","title":"Active cell migration is critical for steady-state epithelial turnover in the gut","type":"journal_article","month":"08","date_created":"2019-08-25T22:00:51Z","oa_version":"None","date_published":"2019-08-16T00:00:00Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","pmid":1,"scopus_import":"1","quality_controlled":"1","abstract":[{"lang":"eng","text":"Steady-state turnover is a hallmark of epithelial tissues throughout adult life. Intestinal epithelial turnover is marked by continuous cell migration, which is assumed to be driven by mitotic pressure from the crypts. However, the balance of forces in renewal remains ill-defined. Combining biophysical modeling and quantitative three-dimensional tissue imaging with genetic and physical manipulations, we revealed the existence of an actin-related protein 2/3 complex–dependent active migratory force, which explains quantitatively the profiles of cell speed, density, and tissue tension along the villi. Cells migrate collectively with minimal rearrangements while displaying dual—apicobasal and front-back—polarity characterized by actin-rich basal protrusions oriented in the direction of migration. We propose that active migration is a critical component of gut epithelial turnover."}],"isi":1,"author":[{"first_name":"Denis","full_name":"Krndija, Denis","last_name":"Krndija"},{"first_name":"Fatima El","full_name":"Marjou, Fatima El","last_name":"Marjou"},{"last_name":"Guirao","full_name":"Guirao, Boris","first_name":"Boris"},{"full_name":"Richon, Sophie","last_name":"Richon","first_name":"Sophie"},{"first_name":"Olivier","full_name":"Leroy, Olivier","last_name":"Leroy"},{"first_name":"Yohanns","full_name":"Bellaiche, Yohanns","last_name":"Bellaiche"},{"last_name":"Hannezo","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6005-1561","first_name":"Edouard B"},{"first_name":"Danijela Matic","full_name":"Vignjevic, Danijela Matic","last_name":"Vignjevic"}],"citation":{"ista":"Krndija D, Marjou FE, Guirao B, Richon S, Leroy O, Bellaiche Y, Hannezo EB, Vignjevic DM. 2019. Active cell migration is critical for steady-state epithelial turnover in the gut. Science. 365(6454), 705–710.","ama":"Krndija D, Marjou FE, Guirao B, et al. Active cell migration is critical for steady-state epithelial turnover in the gut. <i>Science</i>. 2019;365(6454):705-710. doi:<a href=\"https://doi.org/10.1126/science.aau3429\">10.1126/science.aau3429</a>","short":"D. Krndija, F.E. Marjou, B. Guirao, S. Richon, O. Leroy, Y. Bellaiche, E.B. Hannezo, D.M. Vignjevic, Science 365 (2019) 705–710.","chicago":"Krndija, Denis, Fatima El Marjou, Boris Guirao, Sophie Richon, Olivier Leroy, Yohanns Bellaiche, Edouard B Hannezo, and Danijela Matic Vignjevic. “Active Cell Migration Is Critical for Steady-State Epithelial Turnover in the Gut.” <i>Science</i>. American Association for the Advancement of Science, 2019. <a href=\"https://doi.org/10.1126/science.aau3429\">https://doi.org/10.1126/science.aau3429</a>.","apa":"Krndija, D., Marjou, F. E., Guirao, B., Richon, S., Leroy, O., Bellaiche, Y., … Vignjevic, D. M. (2019). Active cell migration is critical for steady-state epithelial turnover in the gut. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aau3429\">https://doi.org/10.1126/science.aau3429</a>","mla":"Krndija, Denis, et al. “Active Cell Migration Is Critical for Steady-State Epithelial Turnover in the Gut.” <i>Science</i>, vol. 365, no. 6454, American Association for the Advancement of Science, 2019, pp. 705–10, doi:<a href=\"https://doi.org/10.1126/science.aau3429\">10.1126/science.aau3429</a>.","ieee":"D. Krndija <i>et al.</i>, “Active cell migration is critical for steady-state epithelial turnover in the gut,” <i>Science</i>, vol. 365, no. 6454. American Association for the Advancement of Science, pp. 705–710, 2019."},"intvolume":"       365","department":[{"_id":"EdHa"}],"publication_status":"published","external_id":{"isi":["000481688700050"],"pmid":["31416964"]},"volume":365,"year":"2019","publisher":"American Association for the Advancement of Science","day":"16","language":[{"iso":"eng"}],"date_updated":"2023-08-29T07:16:40Z","_id":"6832","publication":"Science","issue":"6454","doi":"10.1126/science.aau3429","page":"705-710"}